{"id":"W2915560143","doi":"10.1186/s12935-019-0725-1","title":"Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target","year":2019,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stornoway Diamond (Canada); BC Cancer Agency; Genome British Columbia; University of British Columbia","funders":"University of British Columbia; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Serous ovarian cancer; Serous fluid; Ovarian cancer; MEK inhibitor; Medicine; Cancer research; EGFR inhibitors; Oncology; Internal medicine; Cancer; Biology; MAPK/ERK pathway; Epidermal growth factor receptor; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009620767,0.0001980503,0.0003400313,0.0001113495,0.000021274,0.00002033587,0.0001766515,0.00009574591,0.007627519],"category_scores_gemma":[0.000003904872,0.0001828613,0.0001481313,0.0001628972,0.00005102483,0.0001224182,0.00003840492,0.0001554313,0.00003020821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001064478,"about_ca_system_score_gemma":0.0004025638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002247296,"about_ca_topic_score_gemma":0.0009039885,"domain_scores_codex":[0.9984442,0.00002967127,0.0003885933,0.0004207194,0.0004621477,0.0002546392],"domain_scores_gemma":[0.9992617,0.00003432928,0.0001947363,0.0002626971,0.0001549702,0.00009151886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006726127,0.003029169,0.9060677,0.001357151,0.002363033,0.0002827373,0.003148531,0.00169774,0.03141017,0.002438811,0.03053715,0.01094173],"study_design_scores_gemma":[0.03023936,0.0007192362,0.6649553,0.003622887,0.0005156741,0.00001890795,0.000734597,0.004267996,0.1581988,0.001391086,0.1343175,0.001018557],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265711,0.02147457,0.000142633,0.01721249,0.004922989,0.001347285,0.0006595453,0.00004860069,0.02762078],"genre_scores_gemma":[0.9889929,0.002268682,0.0006344096,0.001450687,0.0003717557,0.0002080132,0.00004675864,0.00003493855,0.005991851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2411123,"threshold_uncertainty_score":0.9932796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009495629598201496,"score_gpt":0.2673511730442593,"score_spread":0.2578555434460578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}