{"id":"W2915560143","doi":"10.1186/s12935-019-0725-1","title":"Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target","year":2019,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stornoway Diamond (Canada); BC Cancer Agency; Genome British Columbia; University of British Columbia","funders":"University of British Columbia; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Serous ovarian cancer; Serous fluid; Ovarian cancer; MEK inhibitor; Medicine; Cancer research; EGFR inhibitors; Oncology; Internal medicine; Cancer; Biology; MAPK/ERK pathway; Epidermal growth factor receptor; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005042477,0.0002656613,0.0004322294,0.0008379634,0.0001461934,0.0006708353,0.0002638874,0.0002552129,0.0009601292],"category_scores_gemma":[0.0007387904,0.0001034667,0.0001740406,0.0005686753,0.0002238919,0.0002559608,0.0001594393,0.0004136951,0.0002141373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003559335,"about_ca_system_score_gemma":0.0002163098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004812817,"about_ca_topic_score_gemma":0.0007952637,"domain_scores_codex":[0.9998248,0.00004469105,0.00002002475,0.00002692765,0.00006343247,0.0000201002],"domain_scores_gemma":[0.9995236,0.0001321945,0.0001889245,0.00003215754,0.00007955819,0.00004344402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002324623,0.0002295265,0.6038609,0.0005227716,0.000161887,0.001177179,0.0001276698,0.001150667,0.2878084,0.0002164008,0.0009595387,0.1014604],"study_design_scores_gemma":[0.00008433916,0.00206153,0.7824365,0.00008180187,0.0003543042,0.008608356,0.0002283449,0.005085408,0.1926622,0.0003974805,0.007975559,0.00002418546],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840102,0.0109334,0.001982124,0.0002884572,0.00001716072,0.00006212504,0.0004597863,0.0001228843,0.002123931],"genre_scores_gemma":[0.996917,0.001123048,0.001296788,0.00004953107,0.000009180038,0.00001698887,0.0003193525,0.000006695233,0.0002614186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009601292,"threshold_uncertainty_score":0.003211975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009495629598201496,"score_gpt":0.2673511730442593,"score_spread":0.2578555434460578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}