{"id":"W2915574395","doi":"10.1101/555821","title":"Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Parkinsonfonden; National Institutes of Health; Ludmer Centre for Neuroinformatics and Mental Health; H. Lundbeck A/S; Knut och Alice Wallenbergs Stiftelse; Servier; Vetenskapsrådet; Eisai; Lunds Universitet; Government of Canada; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Australian Government; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; Genentech; Marcus och Amalia Wallenbergs minnesfond; Alzheimer's Disease Neuroimaging Initiative; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Avid Radiopharmaceuticals; Parkinson Research Foundation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neuroscience; Neurodegeneration; Amyloid (mycology); Human Connectome Project; Pathological; Tau pathology; Human brain; Connectome; Disease; Alzheimer's disease; Psychology; Biology; Pathology; Functional connectivity; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006369529,0.0004161119,0.0003074249,0.000446356,0.0001747055,0.0003856698,0.0002396363,0.0004930318,0.0005213552],"category_scores_gemma":[0.001889024,0.0002050206,0.0003493466,0.0002346203,0.0003461294,0.0004201369,0.0002332937,0.0002822945,0.000115219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003362459,"about_ca_system_score_gemma":0.0002160359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005225053,"about_ca_topic_score_gemma":0.003381864,"domain_scores_codex":[0.9998653,0.00006183545,0.000007156649,0.0000345643,0.00002061367,0.00001049078],"domain_scores_gemma":[0.9995744,0.0002285557,0.00008803898,0.0000452854,0.00003696968,0.00002675029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0006343516,0.0002473332,0.1326849,0.0001220897,0.0003133914,0.0008667057,0.0006025954,0.8042043,0.03363185,0.003898781,0.0006877191,0.02210604],"study_design_scores_gemma":[0.00003169198,0.0002037485,0.04097886,0.00001779611,0.0000360336,0.0004402146,0.00007909583,0.9467635,0.003618934,0.007524856,0.000283819,0.00002159905],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886422,0.0001707214,0.0106312,0.00007435594,0.000005929736,0.00001078703,0.00008689112,0.00004574432,0.000332234],"genre_scores_gemma":[0.9976087,0.00008435161,0.002059705,0.00001124242,0.000002543273,0.000006866071,0.00007276482,0.000003289903,0.0001507331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005225053,"threshold_uncertainty_score":0.01038933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05824010078505811,"score_gpt":0.3162232135872411,"score_spread":0.2579831128021831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}