{"id":"W2915627369","doi":"10.1021/acsmedchemlett.8b00613","title":"<sup>18</sup>F-Labeled PET Probe Targeting Enhancer of Zeste Homologue 2 (EZH2) for Cancer Imaging","year":2019,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Cancer Research Society","keywords":"EZH2; Epigenetics; Methylation; Cancer research; Positron emission tomography; Chemistry; IC50; Molecular biology; Cell culture; Histone H3; Biology; Medicine; Biochemistry; Nuclear medicine; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003309639,0.0002275452,0.0002760517,0.00002554262,0.00005770147,0.00001231738,0.0002443233,0.00009772817,0.0001205248],"category_scores_gemma":[0.0001276575,0.0002186288,0.0001080371,0.00008244538,0.0001150767,0.000007173986,0.00007692249,0.0001459701,0.000003168649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003580864,"about_ca_system_score_gemma":0.00009470656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005276296,"about_ca_topic_score_gemma":0.000002135245,"domain_scores_codex":[0.9985277,0.00002905311,0.0003715086,0.0004699176,0.0002246601,0.0003771654],"domain_scores_gemma":[0.9991259,0.00004631783,0.000238484,0.0003360882,0.0001623244,0.00009089223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008769375,0.00002804241,0.006628938,0.0003324664,0.00006211014,0.00000522652,0.0001013609,0.0006041955,0.9896386,0.000001721413,0.001527788,0.0009818573],"study_design_scores_gemma":[0.0009862729,0.00006093563,0.0002271208,0.00009602823,0.00005739492,0.000007255926,0.0001589999,0.0004941585,0.9878744,0.00002697821,0.009761541,0.0002489141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927629,0.002699711,0.002489842,0.001135129,0.0001398305,0.0003508263,0.00003949219,0.00001302818,0.0003692996],"genre_scores_gemma":[0.9960679,0.0002337062,0.001582099,0.0005746029,0.0006423143,0.00009343519,0.000363646,0.00004067064,0.0004015603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008233753,"threshold_uncertainty_score":0.8915424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007596031437616691,"score_gpt":0.2610958114391707,"score_spread":0.253499780001554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}