{"id":"W2915627369","doi":"10.1021/acsmedchemlett.8b00613","title":"<sup>18</sup>F-Labeled PET Probe Targeting Enhancer of Zeste Homologue 2 (EZH2) for Cancer Imaging","year":2019,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Cancer Research Society","keywords":"EZH2; Epigenetics; Methylation; Cancer research; Positron emission tomography; Chemistry; IC50; Molecular biology; Cell culture; Histone H3; Biology; Medicine; Biochemistry; Nuclear medicine; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182206,0.0003528304,0.0002308527,0.000167954,0.0001915372,0.0001943271,0.0003295411,0.0006725746,0.002796041],"category_scores_gemma":[0.0001452801,0.0001692579,0.0001413553,0.00019913,0.000229936,0.0003513815,0.0001453604,0.0004010318,0.000746105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003453398,"about_ca_system_score_gemma":0.000174782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006285851,"about_ca_topic_score_gemma":0.0007728825,"domain_scores_codex":[0.99993,0.0000219449,0.000003018248,0.00001659979,0.00001083373,0.00001759934],"domain_scores_gemma":[0.9999403,0.00001987868,0.0000153917,0.000005150611,0.000008902421,0.00001032618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003712261,0.00004171373,0.000162814,0.000108492,0.00001267634,0.0003237589,0.00002647166,0.0004075894,0.9900388,0.0007888547,0.0008769203,0.006840684],"study_design_scores_gemma":[0.00008502955,0.0006236631,0.0007667125,0.00001037381,0.00002500415,0.001266036,0.00002281301,0.00186781,0.9729936,0.0001195908,0.02220617,0.00001314428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8140917,0.02436995,0.1225383,0.002109708,0.0003078585,0.0004171787,0.001960201,0.0006796984,0.03352528],"genre_scores_gemma":[0.8873094,0.007576635,0.08957648,0.0009369851,0.00009434428,0.0003407586,0.00170598,0.0001393813,0.01231994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002796041,"threshold_uncertainty_score":0.009353757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007596031437616691,"score_gpt":0.2610958114391707,"score_spread":0.253499780001554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}