{"id":"W2915698847","doi":"10.1016/j.clinthera.2019.01.017","title":"A Single-dose, Comparative Bioavailability Study of a Formulation containing OM3 as Phospholipid and Free Fatty Acid to an Ethyl Ester Formulation in the Fasting and Fed States","year":2019,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Fatty Acid Research and Health","field":"Nursing","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Western University; Supratek Pharma (Canada); Pharma Medica Research (Canada); BioPhage Pharma (Canada)","funders":"Regeneron Pharmaceuticals; Sanofi; Aegerion Pharmaceuticals; Amgen","keywords":"Bioavailability; Medicine; Cmax; Docosahexaenoic acid; Meal; Pharmacokinetics; Crossover study; Eicosapentaenoic acid; Fatty acid; Pharmacology; Food science; Internal medicine; Chemistry; Biochemistry; Polyunsaturated fatty acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002704076,0.0001581739,0.0004328271,0.0000794576,0.0001469249,0.00009324184,0.0001894736,0.0001230429,0.000007219548],"category_scores_gemma":[0.0003194863,0.0001136373,0.00003743084,0.0002292008,0.0001046494,0.0002720522,0.0000974861,0.0004416732,0.000003592058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005359748,"about_ca_system_score_gemma":0.00003401599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002522381,"about_ca_topic_score_gemma":0.001146435,"domain_scores_codex":[0.997385,0.000826714,0.0007775811,0.0003729842,0.000319375,0.0003184035],"domain_scores_gemma":[0.9969109,0.002168652,0.0002140554,0.000420788,0.0001605486,0.0001250918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005067357,0.001268381,0.8953782,0.00006990065,0.00003863275,7.657715e-7,0.05137013,0.00007799281,0.005918122,0.00009070465,0.000002939803,0.0407169],"study_design_scores_gemma":[0.005346925,0.01827473,0.9218593,0.00008655975,0.00003330797,0.000001938848,0.02334265,0.02562487,0.003038113,0.002122884,0.00008890806,0.0001798629],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965504,0.0001005512,0.0002377538,0.0009987553,0.0001178006,0.001887446,0.000009489465,0.00002076549,0.0000770065],"genre_scores_gemma":[0.9973599,0.00001375743,0.001361651,0.001174241,0.00004669763,0.00001546822,0.00001204103,0.00001412811,0.000002057915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04053704,"threshold_uncertainty_score":0.4633994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2273195481318258,"score_gpt":0.4593779968017172,"score_spread":0.2320584486698914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}