{"id":"W2915787082","doi":"10.1101/560623","title":"Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Calgary; McMaster University","funders":"FP7 People: Marie-Curie Actions; National Center for Complementary and Integrative Health; NIH Clinical Center; National Institute of Mental Health; Helse Sør-Øst RHF; Canadian Institutes of Health Research; Children's Hospital Foundation; National Institutes of Health; Gratama Stichting; Norges Forskningsråd; Siemens Healthineers; Medical Research Council; National Alliance for Research on Schizophrenia and Depression; Leids Universitair Medisch Centrum; University of Minnesota; Vetenskapsrådet; University of California, San Francisco; EU Joint Programme – Neurodegenerative Disease Research; Rivierduinen; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; Alberta Children's Hospital Foundation; Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya; National Institute of Child Health and Human Development; Centro de Investigación Biomédica en Red de Salud Mental; ZonMw; National Health and Medical Research Council; Ministerio de Ciencia e Innovación; University of California, San Diego; University of New South Wales; FP7 Health; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; H. Lundbeck A/S; Health Research Board; National Research Foundation; National Institute for Health and Care Research; Instituto de Salud Carlos III; University of Cape Town; Russian Science Foundation; Science Foundation Ireland; Nova Scotia Health Research Foundation; National Science Foundation; UK Research and Innovation; Brain and Behavior Research Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Dalhousie University; University of Texas Health Science Center at Houston; Wellcome Trust; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya; Irish Research Council","keywords":"Major depressive disorder; Depression (economics); Brain aging; Late life depression; Atrophy; Internal medicine; Psychology; Brain size; Medicine; Cardiology; Psychiatry; Magnetic resonance imaging; Amygdala; Cognition; Disease; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003816035,0.0006737633,0.0007159092,0.0006830069,0.0004147793,0.000792479,0.0007151925,0.0005039707,0.0007491148],"category_scores_gemma":[0.006737755,0.0002786724,0.001160133,0.00062238,0.0001689186,0.0003574789,0.001312458,0.000412708,0.0004572419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003199598,"about_ca_system_score_gemma":0.0003104148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01044504,"about_ca_topic_score_gemma":0.01055799,"domain_scores_codex":[0.9991733,0.0003224992,0.00009726413,0.0002429203,0.0001059864,0.00005792231],"domain_scores_gemma":[0.9965578,0.0008731515,0.0008531812,0.0007588995,0.0006322818,0.0003246521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007545024,0.00005864524,0.9872128,0.00006342526,0.001223002,0.00005447894,0.0001509532,0.0004001074,0.0002291368,0.00004110055,0.00357146,0.006240367],"study_design_scores_gemma":[0.00005973881,0.00008934292,0.9967325,0.00003553806,0.0005169344,0.000107704,0.0001665355,0.0009503329,0.00008706713,0.00009085612,0.001152679,0.00001078516],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832478,0.001061387,0.0007131,0.000342284,0.00004776955,0.0000647546,0.01390871,0.00003331193,0.0005808853],"genre_scores_gemma":[0.9674526,0.0003917809,0.0005593472,0.000162401,0.00005611817,0.0001134787,0.03081993,0.00003392652,0.0004104998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01044504,"threshold_uncertainty_score":0.02076846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941839384684533,"score_gpt":0.2302781755527924,"score_spread":0.2108597817059471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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