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Lundbeck A/S; Health Research Board; National Research Foundation; National Institute for Health and Care Research; Instituto de Salud Carlos III; University of Cape Town; Russian Science Foundation; Science Foundation Ireland; Nova Scotia Health Research Foundation; National Science Foundation; UK Research and Innovation; Brain and Behavior Research Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Dalhousie University; University of Texas Health Science Center at Houston; Wellcome Trust; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya; Irish Research Council","keywords":"Major depressive disorder; Depression (economics); Brain aging; Late life depression; Atrophy; Internal medicine; Psychology; Brain size; Medicine; Cardiology; Psychiatry; Magnetic resonance imaging; Amygdala; Cognition; Disease; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00120902,0.001234627,0.001137381,0.0004254968,0.0009647273,0.0006808292,0.0021497,0.0006985702,0.00003802614],"category_scores_gemma":[0.02237034,0.001107379,0.0003640776,0.001258754,0.0004727142,0.0004589085,0.003323985,0.002567962,0.0001588576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004861092,"about_ca_system_score_gemma":0.0004275012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001958851,"about_ca_topic_score_gemma":0.0008411579,"domain_scores_codex":[0.9914194,0.001267267,0.001164525,0.003679691,0.001153901,0.001315238],"domain_scores_gemma":[0.9791857,0.016228,0.001178732,0.002942447,0.0002481162,0.000216989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001066964,0.000855479,0.3555569,0.0003806778,0.0005736516,0.0005469797,0.0006301666,0.005908842,0.6265323,0.001989379,0.005870114,0.00008858309],"study_design_scores_gemma":[0.01055399,0.0001256171,0.7905061,0.0032601,0.0003388782,1.934429e-7,0.0001210627,0.003841896,0.1482548,0.000179924,0.03900966,0.003807876],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699163,0.004601403,0.002378977,0.01418131,0.003929245,0.002800112,0.001500264,0.0006160724,0.00007635685],"genre_scores_gemma":[0.9928539,0.0003509399,0.0005689146,0.004159528,0.0009458451,0.0008093971,0.000002587713,0.0002744889,0.00003436481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4782775,"threshold_uncertainty_score":0.9997332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941839384684533,"score_gpt":0.2302781755527924,"score_spread":0.2108597817059471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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