{"id":"W2915844627","doi":"10.1080/19336896.2019.1583041","title":"Prion-dependent proteome remodeling in response to environmental stress is modulated by prion variant and genetic background","year":2019,"lang":"en","type":"article","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Phenotype; Proteome; Genetics; Cellular stress response; Population; Saccharomyces cerevisiae; Yeast; Cell biology; Gene; Fight-or-flight response","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001402292,0.0002382546,0.0002503576,0.00017199,0.0001228034,0.0003923931,0.0001797059,0.0002067719,0.000422286],"category_scores_gemma":[0.0001988745,0.0001727125,0.0001758478,0.0001559434,0.0002032257,0.0001717167,0.0003595085,0.0004384845,0.000138483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001712249,"about_ca_system_score_gemma":0.0001363756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008405541,"about_ca_topic_score_gemma":0.001374029,"domain_scores_codex":[0.9998982,0.00001392243,0.00001132694,0.00002832385,0.00002999943,0.00001815242],"domain_scores_gemma":[0.9997793,0.00003204586,0.00007715364,0.00002118939,0.00003183307,0.00005856427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004772251,0.00000662261,0.0004304262,0.000007447279,0.000002732431,0.00002830549,0.000009031908,0.00001924284,0.9992633,0.000006339487,0.000005813464,0.0001729586],"study_design_scores_gemma":[0.00001824119,0.0003465793,0.1857918,0.0000105719,0.00003298108,0.0006756247,0.0001870968,0.002776491,0.8088342,0.000125925,0.001170379,0.00003014827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998463,0.0002791928,0.000795218,0.00002567514,0.000005238366,0.000006173327,0.0002146254,0.00002678215,0.0001841379],"genre_scores_gemma":[0.9977881,0.0002791004,0.0009233012,0.00004810376,0.000004234167,0.0000106605,0.0004612092,0.00002203321,0.0004631778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008405541,"threshold_uncertainty_score":0.001671314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005265657616469845,"score_gpt":0.2207127783890328,"score_spread":0.2154471207725629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}