{"id":"W2915850404","doi":"10.1016/j.bpg.2019.02.006","title":"IL12/23 or selective IL23 inhibition for the management of moderate-to-severe Crohn's disease?","year":2019,"lang":"en","type":"review","venue":"Best Practice & Research Clinical Gastroenterology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials; University of Calgary","funders":"Canadian Institutes of Health Research; Canadian Association of Gastroenterology","keywords":"Ustekinumab; Interleukin 23; Interleukin 12; Medicine; Immunology; Crohn's disease; Monoclonal antibody; Immune system; Disease; Internal medicine; Antibody; Interleukin 17; Tumor necrosis factor alpha; Biology; Adalimumab; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005641398,0.0006031017,0.002233186,0.0003763902,0.0004355181,0.00006062029,0.0009653902,0.0008100505,0.0002274475],"category_scores_gemma":[0.002739392,0.0003747859,0.001039053,0.000508174,0.0006731,0.0002136082,0.0008633456,0.001700015,0.00194499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002040279,"about_ca_system_score_gemma":0.0006497945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003838011,"about_ca_topic_score_gemma":0.00005743933,"domain_scores_codex":[0.9886885,0.006659349,0.001693128,0.001346176,0.000262993,0.001349851],"domain_scores_gemma":[0.982627,0.01416385,0.0009042355,0.001240885,0.0008861396,0.0001778525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.05658562,0.004041494,0.0001399563,0.006738316,0.01061376,0.0003414498,0.00006601653,0.000009779415,0.00000243509,0.0004125714,0.01876482,0.9022838],"study_design_scores_gemma":[0.003805354,0.006834028,0.0003950777,0.003012424,0.007203734,0.0001584535,0.0002447677,0.000003884871,0.000002348534,0.00006121713,0.9780349,0.0002437745],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009061884,0.9821508,0.0007109575,0.001754089,0.002040006,0.0105863,0.001254099,0.00005070755,0.0005468613],"genre_scores_gemma":[0.0007355284,0.9857321,0.0007101272,0.0003280234,0.0002617781,0.003049663,0.000788846,0.00009780863,0.008296134],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9592701,"threshold_uncertainty_score":0.9998704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2237989742120212,"score_gpt":0.4807085735546616,"score_spread":0.2569095993426403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}