{"id":"W2915892428","doi":"10.1038/s41598-019-38490-1","title":"Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"National Institute on Alcohol Abuse and Alcoholism; National Health and Medical Research Council; National Institutes of Health; University of Sydney; Ramsay Health Care; Australian Schizophrenia Research Bank; Sylvia and Charles Viertel Charitable Foundation; Australian Government; Murdoch Children's Research Institute; Pratt Foundation; Medical Research Council; Children’s Hospital of Wisconsin Research Institute","keywords":"Schizophrenia (object-oriented programming); Ubiquitin; Proteasome; Pathogenesis; Medicine; Internal medicine; Psychiatry; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001568598,0.0002343824,0.000219048,0.0007044768,0.0003416463,0.0003173306,0.00008815434,0.0002297938,0.0008050611],"category_scores_gemma":[0.0006789377,0.0001687282,0.00008252628,0.0003997126,0.000184546,0.0001309234,0.0002497497,0.0002048678,0.0001306589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002095152,"about_ca_system_score_gemma":0.0000942181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002936645,"about_ca_topic_score_gemma":0.003074521,"domain_scores_codex":[0.9998846,0.00002166908,0.00001481935,0.00003249414,0.00002633866,0.00002013699],"domain_scores_gemma":[0.9998324,0.00001838502,0.0000816335,0.00001292815,0.00002558815,0.00002899807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001184461,0.00006086995,0.9503524,0.00005240791,0.00008733664,0.0009053923,0.0008529385,0.00005588985,0.0377025,0.00005024518,0.0001848922,0.008510547],"study_design_scores_gemma":[0.000006107328,0.0001118332,0.9972271,0.000006977874,0.00002043151,0.0009539417,0.0002343359,0.0000425619,0.001168765,0.00004200254,0.0001821595,0.000003730196],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995229,0.0002167361,0.00003372275,0.00001192096,0.000001923588,0.000001883363,0.00008420261,0.000001812951,0.0001248381],"genre_scores_gemma":[0.9993605,0.0002199932,0.0001014833,0.00001626362,0.000003589138,0.000003871734,0.0001206464,0.000001063217,0.0001725158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002936645,"threshold_uncertainty_score":0.00583905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006346548196626378,"score_gpt":0.2172706268953443,"score_spread":0.210924078698718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}