{"id":"W2915958314","doi":"10.1096/fasebj.23.1_supplement.717.20","title":"Phytosterols induce changes in hepatic protein expression patterns and increase cholesterol biosynthesis and sterol efflux in a hypercholesterolemic animal model","year":2009,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cholesterol; Sterol; Internal medicine; Endocrinology; Sterol regulatory element-binding protein; Metabolism; Cholesterol 7 alpha-hydroxylase; Biosynthesis; Liver X receptor; Chemistry; Biology; Biochemistry; Gene; Nuclear receptor; Medicine; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672884,0.0003029601,0.0004031115,0.0004802354,0.0001990442,0.0002993882,0.0001464594,0.0002894267,0.001842546],"category_scores_gemma":[0.000073023,0.0002574385,0.0004510233,0.0002134068,0.0003838659,0.000223782,0.0002150468,0.0008822676,0.0004528869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000320251,"about_ca_system_score_gemma":0.0002307886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176046,"about_ca_topic_score_gemma":0.001626948,"domain_scores_codex":[0.9998363,0.00001872555,0.00001697453,0.00004682229,0.00003130041,0.00004979821],"domain_scores_gemma":[0.999882,0.000009375223,0.00002654552,0.00002204764,0.00001715549,0.00004281597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008730273,0.0001124532,0.0004995329,0.00003753206,0.000009767134,0.00006308538,0.00002610019,0.00001991796,0.997516,0.00003492372,0.00003954109,0.0007680361],"study_design_scores_gemma":[0.0001191643,0.003283223,0.02469737,0.00001399503,0.00007444555,0.0002565442,0.0001427174,0.0008034091,0.9681405,0.00009665922,0.002360411,0.00001159569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969796,0.0006851319,0.0009537471,0.0001059472,0.00004346787,0.00003021422,0.0003353292,0.00006447599,0.0008021191],"genre_scores_gemma":[0.9869921,0.001015029,0.001563077,0.0001472081,0.00002625812,0.0001224271,0.0006648774,0.00003423003,0.009434723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842546,"threshold_uncertainty_score":0.006163955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01943763079774473,"score_gpt":0.2546941447316237,"score_spread":0.2352565139338789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}