{"id":"W2915965247","doi":"10.25376/hra.7276502","title":"Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia","year":2018,"lang":"en","type":"book-chapter","venue":"Figshare","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fogarty International Center; Canadian Institute for Advanced Research; Cincinnati Children's Hospital Medical Center; Doris Duke Charitable Foundation","keywords":"Malaria; Medicine; Placebo; Sickle cell anemia; Anemia; Fetal hemoglobin; Internal medicine; Incidence (geometry); Parasitemia; Neutropenia; Adverse effect; Pediatrics; Immunology; Chemotherapy; Plasmodium falciparum; Pregnancy; Biology; Pathology; Fetus; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007831395,0.0003991851,0.001103902,0.000217738,0.0002330243,0.0004044335,0.0003618942,0.0009035346,0.00173024],"category_scores_gemma":[0.0008921212,0.000204371,0.0008754711,0.0001872224,0.0004498357,0.0004395987,0.0002700388,0.001324362,0.0001191699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002503944,"about_ca_system_score_gemma":0.0004743715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004657129,"about_ca_topic_score_gemma":0.001479408,"domain_scores_codex":[0.9997757,0.0001419583,0.0000149086,0.00002769834,0.00001798186,0.00002171935],"domain_scores_gemma":[0.9995517,0.0001470276,0.000128668,0.00002081345,0.00002293253,0.0001289129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.843658,0.01092902,0.003058106,0.003550887,0.001633728,0.000299262,0.0002292939,0.0007846938,0.01403115,0.0006069356,0.00144609,0.1197728],"study_design_scores_gemma":[0.8233466,0.1633587,0.007096154,0.0002370355,0.0007122935,0.0002622755,0.00006707549,0.0006752152,0.001632425,0.0002400543,0.002354848,0.00001733774],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985276,0.01133528,0.0004779389,0.0005066294,0.0002208325,0.0008308252,0.0002732863,0.0000442358,0.001035054],"genre_scores_gemma":[0.9884289,0.006105023,0.001790416,0.0007438306,0.0002105995,0.001349939,0.0002984369,0.000007632899,0.001065333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173024,"threshold_uncertainty_score":0.005788207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04125285090499641,"score_gpt":0.2398443977023928,"score_spread":0.1985915467973964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}