{"id":"W2915976330","doi":"10.1152/physrev.00019.2018","title":"The Orphan Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homolog-1: Structure, Regulation, and Essential Roles in Mammalian Reproduction","year":2019,"lang":"en","type":"review","venue":"Physiological Reviews","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Nuclear receptor; Steroidogenic factor 1; Biology; Liver receptor homolog-1; Orphan receptor; Cell biology; Neuron-derived orphan receptor 1; Receptor; Transcription factor; Estrogen receptor; Endocrinology; Nuclear receptor coactivator 1; Internal medicine; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003737198,0.0004595715,0.001097291,0.00004575487,0.0001567558,0.00005699005,0.0002515744,0.0006806776,0.00005238846],"category_scores_gemma":[0.0003268643,0.000248427,0.0002891816,0.0001506016,0.0002449404,0.00001072296,0.0002692408,0.0004660334,0.00005595305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002753621,"about_ca_system_score_gemma":0.00003319626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004543375,"about_ca_topic_score_gemma":0.000005001772,"domain_scores_codex":[0.9970264,0.0009889398,0.0006218948,0.0009539484,0.0001002179,0.0003085986],"domain_scores_gemma":[0.9987708,0.00005868594,0.0004411468,0.0006048053,0.00003249078,0.00009211455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006887434,0.00003966535,0.00001208545,0.002553204,0.000126315,0.000001821562,0.00003068591,7.350822e-7,0.02305437,0.0001149868,0.007190272,0.966807],"study_design_scores_gemma":[0.0001457127,0.0002845705,0.0001326146,0.0007976372,0.0001413389,0.00003881852,0.000005764913,0.000002007609,0.0002207111,0.00004597768,0.997856,0.0003289141],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03048718,0.9678146,0.000001570387,0.00002028691,0.000304975,0.001328749,0.0000187994,0.00001156647,0.00001223671],"genre_scores_gemma":[0.002925063,0.9958521,0.0000883106,0.00002712904,0.00040676,0.00004722235,0.0002916515,0.00004042044,0.0003213217],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9906657,"threshold_uncertainty_score":0.9999968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0277886895215717,"score_gpt":0.2885187301452048,"score_spread":0.2607300406236331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}