{"id":"W2916070683","doi":"10.1002/pro.3595","title":"Evaluation of a noncanonical Cys40‐Cys55 disulfide linkage for stabilization of single‐domain antibodies","year":2019,"lang":"en","type":"article","venue":"Protein Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Thermostability; Disulfide Linkage; Chemistry; Single-domain antibody; Disulfide bond; Circular dichroism; Crystallography; Solubility; Denaturation (fissile materials); Stereochemistry; Antibody; Biochemistry; Cysteine; Physical chemistry; Biology; Nuclear chemistry; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004156887,0.0002808229,0.0001531772,0.0001097534,0.0001212021,0.0002181878,0.000200866,0.0002020348,0.0004089907],"category_scores_gemma":[0.0002502476,0.00009742289,0.0001938121,0.00009460378,0.0001500962,0.0001289269,0.0001551499,0.0003050923,0.00007431028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446146,"about_ca_system_score_gemma":0.0001432242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003093551,"about_ca_topic_score_gemma":0.0004664971,"domain_scores_codex":[0.9997664,0.00007676681,0.00002744094,0.00004052996,0.00005560325,0.0000331999],"domain_scores_gemma":[0.9997829,0.00004206455,0.00007218683,0.00002459048,0.00003703478,0.0000412548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007370788,0.00003620282,0.0002315128,0.00001669197,0.000006505166,0.00001486496,0.00000788403,0.0001679664,0.998765,0.00002739145,0.000007697755,0.0006446281],"study_design_scores_gemma":[0.000007546369,0.0005016495,0.0006166617,0.000001990443,0.00001089163,0.00005294685,0.000005895255,0.0006156786,0.9978757,0.000006562962,0.0003028419,0.000001682622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998667,0.000172234,0.001023159,0.000009927126,0.000005664846,0.00000869642,0.00001968409,0.000007524194,0.00008609423],"genre_scores_gemma":[0.9975876,0.00009240563,0.00209752,0.00001120583,0.000002767217,0.000006656765,0.00004651807,0.000004459157,0.0001508736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004156887,"threshold_uncertainty_score":0.002198339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07134313191872789,"score_gpt":0.383354462211985,"score_spread":0.3120113302932571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}