{"id":"W2916086954","doi":"10.1371/journal.pgen.1008007","title":"Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci","year":2019,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Ontario Institute for Cancer Research; Hospital for Sick Children; Public Health Ontario; SickKids Foundation; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Genomics; National Institutes of Health; Fondation Pierre Deniker pour la Recherche et la Prévention en Santé Mentale; Association Vaincre la Mucoviscidose; National Heart, Lung, and Blood Institute; Hospital for Sick Children; National Human Genome Research Institute; Agence Nationale de la Recherche; GIS-Institut des Maladies Rares; Ontario Genomics Institute; Cystic Fibrosis Canada; Genome Canada; Cystic Fibrosis Foundation","keywords":"Biology; Locus (genetics); Genetics; Meconium Ileus; Cystic fibrosis; Genome-wide association study; Expression quantitative trait loci; Quantitative trait locus; Allele; Gene; Single-nucleotide polymorphism; Meconium; Genotype; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000982584,0.0003828344,0.0005512441,0.001212333,0.0003340677,0.0008508141,0.0003811335,0.0004431181,0.003073134],"category_scores_gemma":[0.00173709,0.0002825287,0.001005536,0.001195773,0.000380159,0.0002419319,0.001141073,0.0005364151,0.0003986828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003830432,"about_ca_system_score_gemma":0.0004119182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002275628,"about_ca_topic_score_gemma":0.003072999,"domain_scores_codex":[0.9989435,0.0001750534,0.00005157506,0.0005425241,0.0001809103,0.0001065187],"domain_scores_gemma":[0.9989748,0.000438504,0.0002614102,0.0001367859,0.00009277598,0.0000957598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000980848,0.00008557287,0.4046425,0.0003371741,0.001055752,0.0009471204,0.0004591864,0.004436523,0.5091146,0.003185173,0.0008116807,0.07394391],"study_design_scores_gemma":[0.00008945307,0.0003421084,0.9146548,0.00004557101,0.001121006,0.001514988,0.0003596311,0.02570809,0.0461171,0.004412768,0.005577713,0.00005680378],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558826,0.001154292,0.03840045,0.0001138448,0.0000296681,0.00003693066,0.002338882,0.0003450646,0.001698364],"genre_scores_gemma":[0.9757137,0.0002674647,0.02081604,0.0001043101,0.00001520306,0.00005225413,0.00183952,0.000124921,0.001066479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003073134,"threshold_uncertainty_score":0.01028061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674510067738285,"score_gpt":0.2919621770390155,"score_spread":0.2752170763616327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}