{"id":"W291617465","doi":"10.1371/journal.pone.0126532","title":"TGF-β1 Up-Regulates Connective Tissue Growth Factor Expression in Human Granulosa Cells through Smad and ERK1/2 Signaling Pathways","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"Canadian Institutes of Health Research; China Scholarship Council; National Natural Science Foundation of China","keywords":"CTGF; Cell biology; SMAD; Growth factor; Transforming growth factor; Transforming growth factor beta; Gene knockdown; Biology; Granulosa cell; Connective tissue; Signal transduction; Endocrinology; Chemistry; Internal medicine; Follicular phase; Cell culture; Medicine; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002336775,0.0002718641,0.0003484148,0.00009801233,0.0001129088,0.00005493875,0.0002380242,0.0002306264,0.00007172634],"category_scores_gemma":[0.0003377105,0.000267058,0.00004284633,0.0001500931,0.0001461544,0.00002384926,0.000307868,0.0002368777,0.00001880056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006352113,"about_ca_system_score_gemma":0.00006885195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001837356,"about_ca_topic_score_gemma":0.00007792645,"domain_scores_codex":[0.9980179,0.0002165033,0.0002681345,0.0006548446,0.0003909507,0.0004516413],"domain_scores_gemma":[0.9989917,0.00007958661,0.00009068369,0.0003460398,0.0002857216,0.0002062205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001289451,0.0003623863,0.00637846,0.00008124273,0.00007442832,0.00001399173,0.00150285,0.000001992785,0.9911194,0.00007609223,0.00009345713,0.0001667777],"study_design_scores_gemma":[0.001365618,0.0006269544,0.001502367,0.0001326508,0.00002091196,0.000002350707,0.0005167588,0.00001531593,0.9939026,0.001462665,0.000120034,0.0003318316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976736,0.0009421479,0.0001334385,0.0000687782,0.00004774321,0.000590533,0.00008492804,0.0000316316,0.000427209],"genre_scores_gemma":[0.9985727,0.0000701898,0.0006403074,0.00003281486,0.0001726908,0.00006382162,0.0001048822,0.00004968108,0.0002928973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004876093,"threshold_uncertainty_score":0.9999782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08830681845672086,"score_gpt":0.2894125347238795,"score_spread":0.2011057162671586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}