{"id":"W2916182471","doi":"10.1182/blood-2018-99-111479","title":"Updated Results from an Open-Label, Multicenter, Expanded Treatment Protocol (ETP) Phase (Ph) 3b Study of Ruxolitinib (RUX) in Patients (Pts) with Polycythemia Vera (PV) Who Were Hydroxyurea (HU) Resistant or Intolerant and for Whom No Alternative Treatment (Tx) Was Available","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of British Columbia","funders":"","keywords":"Medicine; Discontinuation; Ruxolitinib; Population; Internal medicine; Clinical endpoint; Gastroenterology; Surgery; Clinical trial; Pediatrics; Myelofibrosis; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009630714,0.0006472008,0.001407598,0.0005719829,0.0004650878,0.001631141,0.001009149,0.00100374,0.00523909],"category_scores_gemma":[0.009142123,0.0005021328,0.001666943,0.001091064,0.0003180396,0.001426211,0.000781994,0.002115623,0.001035649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006737746,"about_ca_system_score_gemma":0.001083974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001125217,"about_ca_topic_score_gemma":0.003007209,"domain_scores_codex":[0.9965436,0.001939819,0.0003801635,0.0003006105,0.0005691362,0.0002666771],"domain_scores_gemma":[0.9896021,0.003452471,0.003674551,0.0009474663,0.001397914,0.0009254813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5829452,0.00918811,0.09817079,0.003066317,0.008217849,0.0004645873,0.0004806308,0.004214152,0.01948953,0.0006362197,0.06824182,0.204885],"study_design_scores_gemma":[0.2328145,0.1203203,0.5514844,0.0007284016,0.01342449,0.001953814,0.0003701585,0.002983464,0.01053005,0.001416451,0.06376759,0.000206405],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8186019,0.009211971,0.003458119,0.002706561,0.0004401563,0.004499953,0.1474113,0.0002805879,0.01338954],"genre_scores_gemma":[0.8755882,0.002878678,0.005749834,0.003223152,0.00030154,0.003573813,0.1045717,0.0001263006,0.003986691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009630714,"threshold_uncertainty_score":0.05093265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05792644211943544,"score_gpt":0.3666678888084303,"score_spread":0.3087414466889949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}