{"id":"W2916190956","doi":"10.1101/561274","title":"Vancomycin Relieves Mycophenolate Mofetil-Induced Gastrointestinal Toxicity by Eliminating Gut Bacterial β-Glucuronidase Activity","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Children's Hospital; University of Calgary","funders":"Cumming School of Medicine, University of Calgary; University of Calgary","keywords":"Mycophenolate; Mycophenolic acid; Toxicity; Pharmacology; Prodrug; Antibiotics; Chemistry; Vancomycin; Cecum; Transplantation; Medicine; Biology; Internal medicine; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008970987,0.0002051794,0.0002113085,0.0001688034,0.0000780843,0.0002137577,0.0001163459,0.000175728,0.0007526295],"category_scores_gemma":[0.0001108696,0.00004171158,0.0001298596,0.00009265073,0.0001266345,0.00007354847,0.0001321705,0.0003974485,0.0001411398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001241079,"about_ca_system_score_gemma":0.0001973752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003788372,"about_ca_topic_score_gemma":0.0007974249,"domain_scores_codex":[0.9999317,0.00001519855,0.00000568826,0.000007699467,0.00001929764,0.00002035269],"domain_scores_gemma":[0.9999254,0.000006300218,0.00002611328,0.000004542198,0.000009122312,0.00002844334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001752258,0.0004906011,0.002674237,0.0001736858,0.00003289748,0.000284554,0.0000185298,0.0001849793,0.9301539,0.0002486596,0.0006413918,0.06334421],"study_design_scores_gemma":[0.0003831234,0.008809008,0.03823396,0.0000936245,0.00009700781,0.002782087,0.000092104,0.002829986,0.9296904,0.0002817917,0.01669117,0.00001589636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891655,0.004804424,0.003495528,0.0003939894,0.00009919728,0.00004023765,0.0000974126,0.0001632261,0.001740496],"genre_scores_gemma":[0.9948243,0.001185884,0.002431497,0.0001124087,0.00002264215,0.00001158954,0.00009779569,0.00001255909,0.001301319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007526295,"threshold_uncertainty_score":0.002517819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695080040215306,"score_gpt":0.2497671730844027,"score_spread":0.2328163726822496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}