{"id":"W2916205053","doi":"10.1101/562652","title":"Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"The Wellcome Trust DBT India Alliance; Department of Biotechnology, Ministry of Science and Technology, India; Sleep Research Society Foundation; Wellcome Trust","keywords":"Prostate cancer; Transactivation; Androgen receptor; Cancer research; Androgen deprivation therapy; Biology; Corepressor; Gene silencing; Downregulation and upregulation; Transcription factor; Repressor; Carcinogenesis; Endocrinology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005397201,0.0001754474,0.0001731374,0.0001915633,0.0001975524,0.0002430738,0.00009542074,0.00008499183,0.001814923],"category_scores_gemma":[0.00005063781,0.00008586372,0.0001939652,0.0001460111,0.0001288334,0.00008066869,0.0001972221,0.0004054041,0.0002743006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002056255,"about_ca_system_score_gemma":0.00017327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090259,"about_ca_topic_score_gemma":0.002454183,"domain_scores_codex":[0.9999125,0.000009744135,0.000006072562,0.00001551896,0.00002470867,0.00003145061],"domain_scores_gemma":[0.9999548,0.000005218811,0.000009353785,0.000004915471,0.00000504903,0.00002076485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001799005,0.00005386181,0.0008046159,0.00007550709,0.00001021271,0.00005984643,0.00001925711,0.00007230584,0.9958444,0.00007172646,0.0002256008,0.002582783],"study_design_scores_gemma":[0.0000422416,0.001681585,0.0860624,0.00001472639,0.00005230966,0.0006699666,0.0001532019,0.001430858,0.8993658,0.0001084137,0.01039751,0.0000210026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933403,0.00367629,0.0004877511,0.0001097958,0.00004796247,0.00001516076,0.0004779528,0.0001094352,0.001735337],"genre_scores_gemma":[0.997588,0.0006528003,0.000161216,0.00003678396,0.000005906632,0.00001059209,0.0003036504,0.000005489753,0.00123552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001814923,"threshold_uncertainty_score":0.006071568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01505802566605667,"score_gpt":0.249925331789508,"score_spread":0.2348673061234513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}