{"id":"W2916379543","doi":"10.1126/science.aav0569","title":"A pharmacological master key mechanism that unlocks the selectivity filter gate in K <sup>+</sup> channels","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Deutsche Forschungsgemeinschaft; Wellcome Trust; Wellcome","keywords":"Key (lock); Mechanism (biology); Selectivity; Chemistry; Filter (signal processing); Computer science; Physics; Biochemistry; Operating system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004087234,0.0003197061,0.0004272287,0.0001374536,0.0005049401,0.001096524,0.0007109261,0.0009990599,0.004688391],"category_scores_gemma":[0.0006330485,0.000259198,0.000392408,0.0001113845,0.001230384,0.001588518,0.0005048176,0.001625685,0.001452576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006032567,"about_ca_system_score_gemma":0.0004815104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001988417,"about_ca_topic_score_gemma":0.0002426607,"domain_scores_codex":[0.9997754,0.00001427431,0.00001336716,0.00005625876,0.00008396315,0.00005689288],"domain_scores_gemma":[0.9998285,0.00005235946,0.00004631413,0.00001944293,0.0000206294,0.00003268366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008663006,0.0001207025,0.0007012242,0.0004654376,0.00004246323,0.0008176365,0.0002146538,0.001489193,0.8740605,0.07644751,0.009005311,0.0357691],"study_design_scores_gemma":[0.0002118412,0.0006284482,0.002188499,0.0000569703,0.00005019295,0.001485852,0.0001845148,0.01272799,0.8697148,0.027207,0.08548298,0.00006096495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7595962,0.02084247,0.1121204,0.02929653,0.007923122,0.0002728859,0.0008689453,0.002701503,0.066378],"genre_scores_gemma":[0.9693785,0.005730224,0.009079026,0.003383437,0.0008394716,0.00007281957,0.0002005829,0.0001335956,0.01118244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004688391,"threshold_uncertainty_score":0.01568419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02551642453517144,"score_gpt":0.2603901749888764,"score_spread":0.234873750453705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}