{"id":"W2916594759","doi":"10.2337/db18-0487","title":"Altered Gut Microbiota Activate and Expand Insulin B15-23–Reactive CD8+ T Cells","year":2019,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council","keywords":"Nod; NOD mice; CD8; Insulin; Cytotoxic T cell; Internal medicine; Endocrinology; Biology; Gut flora; Immunology; Diabetes mellitus; T cell; Proinsulin; Insulin resistance; Antigen; Medicine; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021173,0.0003447523,0.0002073632,0.0002829298,0.00008456457,0.0002151569,0.00007321434,0.0002336613,0.001809785],"category_scores_gemma":[0.00008354127,0.000136521,0.0001949557,0.0001073623,0.0001100522,0.0001436271,0.0001864717,0.0005153787,0.0003672167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001130997,"about_ca_system_score_gemma":0.00006899382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001187204,"about_ca_topic_score_gemma":0.0002376777,"domain_scores_codex":[0.9998502,0.00002682563,0.00001136983,0.00003201062,0.00003043391,0.00004927809],"domain_scores_gemma":[0.9999229,0.0000102364,0.00001682642,0.000007980868,0.000007643994,0.00003449158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658916,0.00003568684,0.0005339187,0.00001276108,0.000001856516,0.00005964982,0.00001146039,0.00001543933,0.9983039,0.00001290413,0.00001185867,0.0008346013],"study_design_scores_gemma":[0.0001139171,0.001619595,0.07240311,0.00002516493,0.00004105495,0.001266967,0.0001950473,0.001087637,0.9201002,0.0001471594,0.002988428,0.00001172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982158,0.0003686178,0.0003997076,0.00002758716,0.00001489755,0.00001347662,0.00009411619,0.00002197442,0.0008438995],"genre_scores_gemma":[0.9968141,0.0003649229,0.0009770319,0.00007447934,0.00001720059,0.00002869163,0.0001425897,0.00001409359,0.00156688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001809785,"threshold_uncertainty_score":0.006054282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003210034009050431,"score_gpt":0.1938894039825208,"score_spread":0.1906793699734704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}