{"id":"W2916620152","doi":"10.1182/blood-2018-10-881441","title":"A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Genomics; Terry Fox Foundation; Canada First Research Excellence Fund; Hospital for Sick Children; Ontario Genomics Institute; Krembil Foundation; University of Toronto; Princess Margaret Hospital Foundation; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Genome Canada","keywords":"Stem cell; Haematopoiesis; Biology; Progenitor cell; Cancer research; Gene silencing; CD34; Cell biology; Hematopoietic stem cell; Leukemia; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130996,0.0004301381,0.0004112959,0.0004718303,0.0002238755,0.0003025756,0.0002704784,0.0003137316,0.002680515],"category_scores_gemma":[0.0002001941,0.000170535,0.0004500622,0.0002897462,0.0002609225,0.0000838675,0.0002406631,0.000375132,0.0008074701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004479181,"about_ca_system_score_gemma":0.0003223864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001286785,"about_ca_topic_score_gemma":0.001644901,"domain_scores_codex":[0.9997737,0.0000287087,0.00002792943,0.00005570221,0.00007347379,0.00004057891],"domain_scores_gemma":[0.9997969,0.00006705683,0.00006006889,0.0000243587,0.00001487523,0.00003670247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005503954,0.00001483422,0.0002235234,0.00001261083,0.000003469561,0.00005335256,0.000004582092,0.0001030159,0.9987069,0.00004313874,0.00002687116,0.0007526131],"study_design_scores_gemma":[0.00001174441,0.0001781564,0.002661148,0.000003768163,0.00001498288,0.0001773962,0.0000120422,0.00150072,0.9942119,0.00002759765,0.001195633,0.000004961647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925344,0.0004532681,0.004452622,0.00007312041,0.00001935315,0.00006054171,0.001438351,0.0002118703,0.0007563981],"genre_scores_gemma":[0.9924467,0.0002233405,0.00378685,0.0000506893,0.000004584188,0.00003917249,0.001980075,0.00005537974,0.001413246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002680515,"threshold_uncertainty_score":0.008967221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01910847136617008,"score_gpt":0.2824806832355092,"score_spread":0.2633722118693391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}