{"id":"W2916658582","doi":"10.1038/s41388-019-0768-8","title":"A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer","year":2019,"lang":"en","type":"article","venue":"Oncogene","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; University of Illinois at Chicago; National Institute of General Medical Sciences; School of Medicine, Vanderbilt University; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; National Cancer Institute; U.S. Department of Health and Human Services; National Natural Science Foundation of China; U.S. Department of Defense","keywords":"Androgen receptor; Enzalutamide; Prostate cancer; Biology; Gene knockdown; Cancer research; splice; Gene isoform; Alternative splicing; Small hairpin RNA; Gene expression; Gene; Molecular biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691993,0.00009049831,0.0002516887,0.0001222418,0.0000130543,0.000003736494,0.00003418192,0.00004875215,0.000127859],"category_scores_gemma":[0.00001796556,0.00007383264,0.00002001023,0.000271836,0.00002100037,0.0000690119,0.000042884,0.0001002848,0.00001240541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001530652,"about_ca_system_score_gemma":0.0001761558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006179968,"about_ca_topic_score_gemma":0.0001703059,"domain_scores_codex":[0.9991831,0.00003697913,0.0001798999,0.0002229502,0.000154144,0.0002229489],"domain_scores_gemma":[0.999686,0.00003395604,0.00005070713,0.00009548299,0.00006631697,0.00006753417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009225661,0.0001071818,0.3429464,0.0001159425,0.00004066716,0.0000264036,0.001927421,0.0000136022,0.6369724,0.00002001389,0.00001197305,0.01689538],"study_design_scores_gemma":[0.01083283,0.0007768198,0.2497806,0.001546851,0.00003896969,0.00002821711,0.001114067,0.002242279,0.7328569,0.00008354233,0.000486404,0.0002125908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885473,0.00834702,1.020181e-7,0.0003050512,0.00002985771,0.0007865564,0.00005254654,0.00000594088,0.001925657],"genre_scores_gemma":[0.9964345,0.001579034,0.0001674447,0.00003472214,0.00002761345,0.0000524817,0.00002377607,0.00001517816,0.001665247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09588446,"threshold_uncertainty_score":0.3010808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137143682473599,"score_gpt":0.3071042915976446,"score_spread":0.2933899233502847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}