{"id":"W2916822920","doi":"10.1016/j.cmet.2019.01.020","title":"Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion","year":2019,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Ludwig Center at Harvard; National Institutes of Health; Roche; Agios Pharmaceuticals; Harvard University; F. Hoffmann-La Roche; Howard Hughes Medical Institute; Susan G. Komen for the Cure; FibroGen; Canadian Institutes of Health Research; American Cancer Society","keywords":"Glutathione; Cancer cell; Programmed cell death; Oxidative stress; Biology; Cell biology; Cancer; Homeostasis; Deubiquitinating enzyme; Cancer research; Biochemistry; Enzyme; Apoptosis; Ubiquitin; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002878246,0.0002291737,0.0003848231,0.00007862123,0.00005134654,0.00002162228,0.0001575764,0.0001743802,0.0001162088],"category_scores_gemma":[0.00002764616,0.0002209746,0.0001216065,0.0001259023,0.0000764703,0.000009138888,0.0001258313,0.0001079288,0.00001434566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009887667,"about_ca_system_score_gemma":0.0001159874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003386141,"about_ca_topic_score_gemma":0.0001550202,"domain_scores_codex":[0.9985973,0.0001209958,0.0002885377,0.0004525801,0.0002096686,0.0003309584],"domain_scores_gemma":[0.9991729,0.00001406521,0.0001872596,0.0003758523,0.000128081,0.0001218293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000139756,0.00006279505,0.0002638349,0.0001276381,0.00003987125,5.26632e-7,0.00008446515,0.00003320506,0.9882074,0.0004704763,0.0002156199,0.01035442],"study_design_scores_gemma":[0.001062013,0.00006982431,0.002969659,0.00002202519,0.0000767414,0.000001794553,0.0001603401,0.00001139299,0.818857,0.0001125317,0.176423,0.0002337267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495068,0.04778685,0.0002607529,0.00005351966,0.001313738,0.0005115196,0.0001273183,0.00001372137,0.0004257318],"genre_scores_gemma":[0.9865644,0.01040116,0.0007332697,0.0001073605,0.0009186171,0.00007011888,0.00005664372,0.00004353468,0.001104922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1762074,"threshold_uncertainty_score":0.9011081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006784350600515387,"score_gpt":0.2323288858122364,"score_spread":0.225544535211721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}