{"id":"W2916822920","doi":"10.1016/j.cmet.2019.01.020","title":"Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion","year":2019,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Ludwig Center at Harvard; National Institutes of Health; Roche; Agios Pharmaceuticals; Harvard University; F. Hoffmann-La Roche; Howard Hughes Medical Institute; Susan G. Komen for the Cure; FibroGen; Canadian Institutes of Health Research; American Cancer Society","keywords":"Glutathione; Cancer cell; Programmed cell death; Oxidative stress; Biology; Cell biology; Cancer; Homeostasis; Deubiquitinating enzyme; Cancer research; Biochemistry; Enzyme; Apoptosis; Ubiquitin; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008701489,0.0001608494,0.0002701367,0.0001770023,0.0002737658,0.0003626517,0.0001562113,0.0001842564,0.0007690808],"category_scores_gemma":[0.00009241752,0.0001013871,0.0001326518,0.0002389236,0.0001576559,0.0002375505,0.0001999995,0.0002627083,0.0002118809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540282,"about_ca_system_score_gemma":0.0001894176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433529,"about_ca_topic_score_gemma":0.003113784,"domain_scores_codex":[0.999935,0.000009197764,0.000006308071,0.00001126651,0.00001170533,0.00002650276],"domain_scores_gemma":[0.9999315,0.000006499169,0.00001635002,0.0000153811,0.00001380786,0.00001655843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003184823,0.00001439361,0.001539398,0.00002503853,0.00001155843,0.00006721639,0.00003218033,0.00006384405,0.9945648,0.0001698488,0.00009000236,0.00310333],"study_design_scores_gemma":[0.00001478252,0.0001597066,0.02670759,0.00000637982,0.00002777779,0.0003779908,0.000115867,0.0007334264,0.966978,0.0001805254,0.00469191,0.000006173233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950532,0.002835121,0.000873197,0.0001943509,0.00001540389,0.000006495358,0.0003433003,0.00004467599,0.0006343176],"genre_scores_gemma":[0.9975809,0.0006093652,0.0003447581,0.00003314395,0.000003947273,0.000005106709,0.0003157454,0.00000633866,0.001100746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433529,"threshold_uncertainty_score":0.002850413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006784350600515387,"score_gpt":0.2323288858122364,"score_spread":0.225544535211721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}