{"id":"W2916867214","doi":"10.1080/15548627.2019.1586261","title":"An autophagy-independent role for ATG16L1: promoting lysosome-mediated plasma membrane repair","year":2019,"lang":"en","type":"letter","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Autophagy; ATG16L1; Lysosome; Biology; Cell biology; Exocytosis; TFEB; Membrane; Homeostasis; Biochemistry; Enzyme; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.0006915136,0.001336247,0.002129986,0.0006220823,0.0003025323,0.0001415692,0.0008677476,0.002666981,0.001582911],"category_scores_gemma":[0.0002853486,0.001235566,0.001399945,0.0004190634,0.0001720627,0.0004021522,0.0001386858,0.002590835,0.001178843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004450676,"about_ca_system_score_gemma":0.001137577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007360779,"about_ca_topic_score_gemma":0.000005520735,"domain_scores_codex":[0.9929767,0.0002830262,0.001378953,0.002129486,0.001454419,0.001777374],"domain_scores_gemma":[0.9950734,0.0006741397,0.000802454,0.002548983,0.0004239371,0.0004771208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002021258,0.002231403,0.0005545822,0.007175837,0.00545168,0.008873109,0.00233045,0.00006580653,0.06386947,0.0002742287,0.8966717,0.01048053],"study_design_scores_gemma":[0.0105402,0.002731792,0.001908432,0.0007635492,0.001629105,0.0005062346,0.000101716,0.02363051,0.07442683,0.0004458336,0.8814622,0.001853663],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.7724655,0.007205486,0.0002775652,0.1714185,0.008406181,0.01971981,0.00248508,0.008732496,0.009289329],"genre_scores_gemma":[0.1998569,0.0002926704,0.002627639,0.7101651,0.02023088,0.001905504,0.01686709,0.001399366,0.0466549],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5726086,"threshold_uncertainty_score":0.9999388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321793534533901,"score_gpt":0.2726881417090961,"score_spread":0.2594702063637571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}