{"id":"W2916881678","doi":"10.1371/journal.ppat.1007564","title":"Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Innovate UK; Medical Research Council; Public Health Agency; Public Health Agency of Canada","keywords":"Virology; Immunogen; Ebola virus; Marburg virus; Ebolavirus; Biology; Filoviridae; Ebola vaccine; Virus; Antibody; Immunology; Viral disease; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003447625,0.001159153,0.0004418633,0.0007644989,0.0002547702,0.0004405932,0.0003590678,0.0009146289,0.002150181],"category_scores_gemma":[0.0002066367,0.000295346,0.0004584005,0.0001423527,0.0004360063,0.0005658864,0.00027119,0.002104402,0.0005602882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506722,"about_ca_system_score_gemma":0.0003378386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006176753,"about_ca_topic_score_gemma":0.001013897,"domain_scores_codex":[0.9996238,0.00004228888,0.00002672593,0.0001174233,0.00007355832,0.0001162653],"domain_scores_gemma":[0.9997341,0.00003684883,0.00006036402,0.0000500357,0.00003229352,0.00008633298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006112058,0.0004504267,0.0001536897,0.00004856541,0.000008542288,0.00004691878,0.0000426562,0.0001315823,0.9964311,0.000237936,0.00007559395,0.001761724],"study_design_scores_gemma":[0.0001989222,0.005467706,0.004382028,0.00003732095,0.00004633478,0.0003292292,0.00007041801,0.001187236,0.9839628,0.0001891654,0.004114839,0.00001398363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905923,0.001171873,0.003451986,0.0002300934,0.0001472341,0.0001697703,0.001228288,0.0001424123,0.002865943],"genre_scores_gemma":[0.9792899,0.00141006,0.006660671,0.0002905377,0.00006322709,0.0002432166,0.001441522,0.00007880364,0.01052203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002150181,"threshold_uncertainty_score":0.007193089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02860701288702774,"score_gpt":0.2421060991935039,"score_spread":0.2134990863064762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}