{"id":"W2916881678","doi":"10.1371/journal.ppat.1007564","title":"Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"Innovate UK; Medical Research Council; Public Health Agency; Public Health Agency of Canada","keywords":"Virology; Immunogen; Ebola virus; Marburg virus; Ebolavirus; Biology; Filoviridae; Ebola vaccine; Virus; Antibody; Immunology; Viral disease; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002494598,0.0001877302,0.0003491456,0.0001308428,0.0001323428,0.00001876088,0.00007831782,0.0001316336,0.00005509452],"category_scores_gemma":[0.00004836121,0.0001302337,0.00009550024,0.0002053157,0.00008496951,0.00007233237,0.0001172723,0.0003498133,0.00002825991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002859819,"about_ca_system_score_gemma":0.00003177661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002320272,"about_ca_topic_score_gemma":0.00006151429,"domain_scores_codex":[0.9986882,0.0001350943,0.0002506356,0.0003473655,0.0002958522,0.0002828527],"domain_scores_gemma":[0.9992558,0.00007372671,0.0001064217,0.0003249978,0.0001186779,0.0001203717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001248736,0.0002465221,0.009110861,0.0003819074,0.00006805346,0.000006682103,0.0002039462,8.796516e-7,0.981832,0.00002654652,0.0001218064,0.007875897],"study_design_scores_gemma":[0.00674041,0.002655314,0.2587945,0.0005577575,0.0003857668,0.0002117695,0.001014259,0.002866726,0.7085701,0.0001051718,0.01744318,0.0006550343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911595,0.003743283,0.00001809007,0.0008461498,0.00007489367,0.001130522,0.0001811109,0.00003347298,0.002813008],"genre_scores_gemma":[0.9957057,0.00332758,0.00006730152,0.0001161734,0.00006866638,0.00004642185,0.00001481081,0.00002965601,0.0006237348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2732619,"threshold_uncertainty_score":0.5310774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02860701288702774,"score_gpt":0.2421060991935039,"score_spread":0.2134990863064762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}