{"id":"W2916896125","doi":"10.1007/978-3-319-98080-5_1","title":"Photoreceptor Cell Replacement Therapy from Stem Cells","year":2018,"lang":"en","type":"book-chapter","venue":"Fundamental biomedical technologies","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Retinitis pigmentosa; Induced pluripotent stem cell; Photoreceptor cell; Transplantation; Stem cell; Retinal; Biology; Retina; Neuroscience; Cell therapy; Cell biology; Stem-cell therapy; Medicine; Embryonic stem cell; Genetics; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001129465,0.0005471499,0.0003864854,0.0001436714,0.0001114318,0.00005280847,0.000710178,0.001294361,0.002478753],"category_scores_gemma":[0.00000851076,0.0004593677,0.0002198333,0.00004686974,0.001069919,0.000003712388,0.0006574196,0.0002979849,0.00075131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008144507,"about_ca_system_score_gemma":0.0001120251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009591718,"about_ca_topic_score_gemma":0.000003583736,"domain_scores_codex":[0.9977443,0.00001390653,0.0004389948,0.0009234675,0.0004784386,0.0004008877],"domain_scores_gemma":[0.998895,0.00001916705,0.0002527608,0.0006864833,0.00004828002,0.0000983183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006633452,0.0001975811,0.0001599542,0.00004621652,0.0003891391,0.00001885481,0.00007043005,2.62611e-8,0.506076,0.0001195201,0.4379269,0.05433204],"study_design_scores_gemma":[0.0005975047,0.0009076376,0.000003616447,0.00004760133,0.00001298424,0.000001264224,0.0002951394,5.017262e-7,0.3545686,0.0009667958,0.642217,0.0003813793],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.530051,0.03957471,0.00053389,0.001806461,0.00651935,0.003804512,0.00258582,0.00204106,0.4130832],"genre_scores_gemma":[0.09915411,0.04081022,0.004293702,0.0009576957,0.0008953398,0.0002091144,0.005179061,0.000286724,0.848214],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.4351308,"threshold_uncertainty_score":0.9997858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306739104145746,"score_gpt":0.2209328650413521,"score_spread":0.2078654739998946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}