{"id":"W2916896125","doi":"10.1007/978-3-319-98080-5_1","title":"Photoreceptor Cell Replacement Therapy from Stem Cells","year":2018,"lang":"en","type":"book-chapter","venue":"Fundamental biomedical technologies","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Retinitis pigmentosa; Induced pluripotent stem cell; Photoreceptor cell; Transplantation; Stem cell; Retinal; Biology; Retina; Neuroscience; Cell therapy; Cell biology; Stem-cell therapy; Medicine; Embryonic stem cell; Genetics; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452357,0.0004948801,0.0003633933,0.000572902,0.0001636018,0.0007069134,0.0004342288,0.0004784088,0.008381388],"category_scores_gemma":[0.0001099326,0.0001577648,0.0002457673,0.0003574256,0.000305188,0.0007656344,0.0004568133,0.001152641,0.004640452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003881466,"about_ca_system_score_gemma":0.0002170904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001812098,"about_ca_topic_score_gemma":0.0004567106,"domain_scores_codex":[0.9999326,0.000005302613,0.000002818163,0.00001018097,0.00004424227,0.000004821072],"domain_scores_gemma":[0.9999766,0.00001072473,0.000002145668,0.000002255397,0.00000522137,0.000002954815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004687946,0.00006842564,0.00006227464,0.001102303,0.00001576219,0.000306205,0.0001108005,0.0008375306,0.1037695,0.07851736,0.06419275,0.7509701],"study_design_scores_gemma":[0.000007001542,0.00002927412,0.0001334784,0.0001662838,0.000008966687,0.0007520138,0.00001641979,0.000446709,0.03038238,0.01380983,0.9542393,0.000008421334],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.008647045,0.4893494,0.09010413,0.003366766,0.005807461,0.0001054375,0.0004722438,0.0007809968,0.4013665],"genre_scores_gemma":[0.03974921,0.2698645,0.02591397,0.001722756,0.001307879,0.0001356267,0.0005228075,0.0002877793,0.6604954],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.008381388,"threshold_uncertainty_score":0.02803856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306739104145746,"score_gpt":0.2209328650413521,"score_spread":0.2078654739998946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}