{"id":"W2916900413","doi":"10.1101/gad.314633.118","title":"BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Genome Canada; Université Laval; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; Centre hospitalier de l'Université Laval; Mount Sinai Hospital","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Ontario Genomics; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institutes of Health; Ludwig Institute for Cancer Research; Institut National Du Cancer; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Genome Canada; Cancer Research Society; Wellcome Trust; Fondation ARC pour la Recherche sur le Cancer","keywords":"DNA damage; Biology; DNA repair; Nucleotide excision repair; Cancer research; Transcription factor; Ku70; Reprogramming; Cell biology; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002812219,0.0001839558,0.0003273748,0.0001315294,0.00005299904,0.00002959883,0.00005791817,0.0000929183,0.0002291938],"category_scores_gemma":[0.00002763772,0.0001560987,0.00002908192,0.0002728799,0.00004133462,0.0000939796,0.00003597759,0.00009444723,0.00004400177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512244,"about_ca_system_score_gemma":0.0002357202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001045428,"about_ca_topic_score_gemma":0.00006130066,"domain_scores_codex":[0.9985479,0.00005295981,0.0003663626,0.0004056043,0.0003608209,0.0002663458],"domain_scores_gemma":[0.999336,0.00006061642,0.0001395861,0.0002793582,0.0001019981,0.00008246506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009617397,0.0006675189,0.8069097,0.0009402567,0.001414772,0.0002347828,0.027881,0.0000902856,0.08314087,0.00009292242,0.002072223,0.07559387],"study_design_scores_gemma":[0.007832449,0.0005455982,0.6809283,0.001470386,0.00009452427,0.00008184478,0.001254398,0.0002237375,0.2980864,0.0002049635,0.008763809,0.0005135629],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973701,0.0005052161,0.00003016522,0.000679205,0.00009256554,0.0008304772,0.000005300897,0.0001427508,0.0003442086],"genre_scores_gemma":[0.9897801,0.000110472,0.008507164,0.0004072484,0.00003579729,0.0002195152,0.0001518589,0.00003205667,0.000755797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2149455,"threshold_uncertainty_score":0.6365521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221979137757796,"score_gpt":0.2520389525896783,"score_spread":0.2398191612121004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}