{"id":"W2916900413","doi":"10.1101/gad.314633.118","title":"BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma","year":2019,"lang":"en","type":"article","venue":"Genes & Development","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Genome Canada; Université Laval; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; Centre hospitalier de l'Université Laval; Mount Sinai Hospital","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Ontario Genomics; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institutes of Health; Ludwig Institute for Cancer Research; Institut National Du Cancer; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Genome Canada; Cancer Research Society; Wellcome Trust; Fondation ARC pour la Recherche sur le Cancer","keywords":"DNA damage; Biology; DNA repair; Nucleotide excision repair; Cancer research; Transcription factor; Ku70; Reprogramming; Cell biology; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272165,0.0002597366,0.0003120721,0.0002993796,0.0001057271,0.000176595,0.0001315513,0.000215715,0.001154227],"category_scores_gemma":[0.0000994751,0.000109575,0.0001561979,0.0001344386,0.0001257315,0.0001151624,0.0001172607,0.0004351574,0.000216114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001561799,"about_ca_system_score_gemma":0.00009702728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002578719,"about_ca_topic_score_gemma":0.0004955643,"domain_scores_codex":[0.9998931,0.00002569829,0.000008929464,0.00002023189,0.00003444357,0.00001761375],"domain_scores_gemma":[0.999912,0.00001043697,0.00002099566,0.00001193822,0.000009302456,0.0000352954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00014827,0.00004365936,0.0002836906,0.00001912781,0.000005215973,0.00007280881,0.000003661554,0.00002708752,0.9980166,0.00003093784,0.00004997251,0.001298986],"study_design_scores_gemma":[0.0001111797,0.001552909,0.03107382,0.000008801174,0.00003588645,0.002381453,0.00003170788,0.001617833,0.9561611,0.00009896761,0.006919425,0.000006928613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918885,0.003537688,0.001612073,0.000130766,0.00004569464,0.00002661182,0.0002659752,0.0001311208,0.002361688],"genre_scores_gemma":[0.9953418,0.0008131411,0.0007402831,0.00007525423,0.00001141972,0.00002794494,0.0004311165,0.00002675063,0.002532381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154227,"threshold_uncertainty_score":0.003861248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221979137757796,"score_gpt":0.2520389525896783,"score_spread":0.2398191612121004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}