{"id":"W2916917493","doi":"10.1007/978-1-4939-9139-6_21","title":"AAV-Mediated Gene Delivery to the Lung","year":2019,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Cystic Fibrosis Canada","keywords":"Genetic enhancement; Gene delivery; Adeno-associated virus; Lung; Nasal administration; Vector (molecular biology); Gene; Virology; Medicine; Biology; Recombinant DNA; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004345673,0.0002917247,0.0003710275,0.0004248356,0.0003711264,0.0008423392,0.0005633456,0.0008877639,0.001761735],"category_scores_gemma":[0.0002093469,0.000346128,0.0003508401,0.0002003998,0.000493497,0.0005211984,0.0004096501,0.001263027,0.0008242285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005808942,"about_ca_system_score_gemma":0.0009357219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002597716,"about_ca_topic_score_gemma":0.002175827,"domain_scores_codex":[0.9997448,0.00004002414,0.00001659321,0.00006385796,0.00007268491,0.00006205815],"domain_scores_gemma":[0.9999126,0.00002755847,0.0000109171,0.00001154355,0.000014927,0.00002240338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000880579,0.00002957008,0.000130416,0.0001243037,0.00001297907,0.0001537716,0.00006718157,0.000226531,0.9878181,0.003025689,0.0002836367,0.008039696],"study_design_scores_gemma":[0.00005628013,0.000363301,0.0009769254,0.00003034198,0.00003960859,0.000545056,0.0000570921,0.002405028,0.9792215,0.000652673,0.01564001,0.00001217368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7037866,0.03045554,0.2381489,0.002122591,0.001299202,0.0006895461,0.001678259,0.001911672,0.01990768],"genre_scores_gemma":[0.925726,0.007341432,0.03719578,0.0003269431,0.0001526379,0.000208947,0.0006056959,0.0001372881,0.02830523],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002597716,"threshold_uncertainty_score":0.005893588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906799950803965,"score_gpt":0.3963332235713412,"score_spread":0.3772652240633015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}