{"id":"W2916917493","doi":"10.1007/978-1-4939-9139-6_21","title":"AAV-Mediated Gene Delivery to the Lung","year":2019,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Cystic Fibrosis Canada","keywords":"Genetic enhancement; Gene delivery; Adeno-associated virus; Lung; Nasal administration; Vector (molecular biology); Gene; Virology; Medicine; Biology; Recombinant DNA; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001960841,0.0002213671,0.0002559375,0.0001533937,0.0000490488,0.00001708018,0.0007133781,0.0002924779,0.0001251554],"category_scores_gemma":[0.0003670323,0.0001717492,0.0001244593,0.000390598,0.0000978965,0.000001740965,0.0004039772,0.0002582447,0.0001519736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003789277,"about_ca_system_score_gemma":0.0001188571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003714284,"about_ca_topic_score_gemma":0.00007698092,"domain_scores_codex":[0.9965775,0.00181448,0.0002831313,0.0006367642,0.0001225317,0.0005655751],"domain_scores_gemma":[0.998677,0.0001143665,0.00005607457,0.0009537027,0.00009022834,0.0001086639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005318128,0.00002402481,0.002759994,0.000005999208,0.00006544255,0.000008325987,0.00003877382,0.0004195617,0.9886912,0.00006610541,0.0003712176,0.007017586],"study_design_scores_gemma":[0.0006307216,0.001354541,0.0004913764,0.000005418626,0.000007618824,0.00001104075,0.00002794509,0.0004391466,0.9655565,0.0001688544,0.03105253,0.0002542965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8516642,0.002855974,0.14323,0.0007855418,0.0002953559,0.0006608847,0.00001899358,0.00001512675,0.0004739219],"genre_scores_gemma":[0.633372,0.0006178576,0.3514023,0.01210211,0.0003475331,0.0003634282,0.0003839312,0.0001493593,0.001261497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2182922,"threshold_uncertainty_score":0.7003727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906799950803965,"score_gpt":0.3963332235713412,"score_spread":0.3772652240633015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}