{"id":"W2917009888","doi":"10.1016/j.blre.2019.02.001","title":"Cellular immunotherapy for acute myeloid leukemia: How specific should it be?","year":2019,"lang":"en","type":"review","venue":"Blood Reviews","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Leukemia and Lymphoma Society","keywords":"Chimeric antigen receptor; Medicine; Myeloid leukemia; Immunotherapy; Cytokine release syndrome; Immunology; Leukemia; Immune system; Hematopoietic stem cell transplantation; Antigen; Myeloid; Cell therapy; Cancer; T cell; Lymphoma; Cancer research; Stem cell; Transplantation; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.002510361,0.001437487,0.009068763,0.0005054077,0.0001506748,0.0001898466,0.001166652,0.001225814,0.005907511],"category_scores_gemma":[0.0001356717,0.0009910343,0.005140232,0.0008697507,0.0001622473,0.0001127928,0.0001798454,0.00195904,0.001344825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006658225,"about_ca_system_score_gemma":0.001276363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006731866,"about_ca_topic_score_gemma":0.000002123399,"domain_scores_codex":[0.9938072,0.0006178122,0.001859731,0.001544274,0.0009596341,0.001211335],"domain_scores_gemma":[0.994443,0.0004798871,0.001014822,0.003446236,0.0002390214,0.0003770428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007189211,0.0001663011,4.325181e-7,0.05220414,0.002167759,0.00007826142,0.00005408337,1.616137e-8,0.002013635,0.00003392043,0.08740131,0.8558083],"study_design_scores_gemma":[0.002566418,0.0007026911,1.126598e-7,0.02455719,0.007965134,0.0003961049,0.00001031125,0.000001134148,0.0002575597,0.000005515977,0.9626816,0.000856231],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001935401,0.9732975,0.000156029,0.0008613135,0.0008773795,0.01998828,0.0002083139,0.00009982065,0.00450942],"genre_scores_gemma":[3.524798e-8,0.8368868,0.001563248,0.0008152715,0.002044725,0.002220981,0.00109304,0.0004624792,0.1549134],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8752803,"threshold_uncertainty_score":0.9998375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2142350377586762,"score_gpt":0.4130453928163727,"score_spread":0.1988103550576965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}