{"id":"W2917009888","doi":"10.1016/j.blre.2019.02.001","title":"Cellular immunotherapy for acute myeloid leukemia: How specific should it be?","year":2019,"lang":"en","type":"review","venue":"Blood Reviews","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Leukemia and Lymphoma Society","keywords":"Chimeric antigen receptor; Medicine; Myeloid leukemia; Immunotherapy; Cytokine release syndrome; Immunology; Leukemia; Immune system; Hematopoietic stem cell transplantation; Antigen; Myeloid; Cell therapy; Cancer; T cell; Lymphoma; Cancer research; Stem cell; Transplantation; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001351374,0.0009588636,0.002208613,0.001401928,0.0002970168,0.0013707,0.001077072,0.002224962,0.003721392],"category_scores_gemma":[0.001578986,0.0003085839,0.0008070759,0.00139915,0.000691187,0.001883741,0.0007707099,0.003982469,0.002215168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009189638,"about_ca_system_score_gemma":0.001570479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265721,"about_ca_topic_score_gemma":0.003001846,"domain_scores_codex":[0.9997048,0.00007717239,0.00003827261,0.00005022,0.00009273696,0.00003688002],"domain_scores_gemma":[0.9993652,0.0003292771,0.00006639098,0.00001684487,0.0001573906,0.00006499371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002102174,0.00007112972,0.0001047434,0.01557985,0.0001653983,0.0001045706,0.00003636584,0.0003069487,0.001201202,0.00376141,0.1180542,0.860404],"study_design_scores_gemma":[0.0001151116,0.0001805755,0.0003121538,0.005053961,0.0002213642,0.0003477199,0.00003609723,0.00007530236,0.0001860413,0.001692082,0.9917614,0.00001820971],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002493356,0.9984741,0.00004365409,0.0007139852,0.0004993415,0.000002213023,0.000009008789,0.000004233636,0.000228503],"genre_scores_gemma":[0.0003530098,0.9973013,0.0001015451,0.001286414,0.0005627772,0.00000606682,0.00002109792,0.000001457773,0.0003662999],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003721392,"threshold_uncertainty_score":0.01244926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2142350377586762,"score_gpt":0.4130453928163727,"score_spread":0.1988103550576965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}