{"id":"W2917034259","doi":"10.1016/j.molmet.2019.02.006","title":"Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation","year":2019,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Diabetes Canada; Vanderbilt University Medical Center; Vanderbilt University","keywords":"Gluconeogenesis; NAD+ kinase; Glycogenolysis; Metabolic pathway; Chemistry; Transmethylation; Endocrinology; Steatosis; Internal medicine; Biochemistry; Biology; Pentose phosphate pathway; Metabolism; Glycolysis; Enzyme; Medicine; Methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407828,0.0003343972,0.0002167823,0.0003632416,0.0001436069,0.0002610138,0.0001789054,0.0002259883,0.001212193],"category_scores_gemma":[0.0001244714,0.0001325982,0.0001837814,0.0001667976,0.0002791013,0.000193417,0.000225391,0.0003201551,0.0001980329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003782713,"about_ca_system_score_gemma":0.0002024832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004813684,"about_ca_topic_score_gemma":0.00108202,"domain_scores_codex":[0.9998695,0.0000247624,0.00001070828,0.00002887235,0.00003912088,0.00002700583],"domain_scores_gemma":[0.9998574,0.00001108689,0.00006321778,0.00001620316,0.00001447219,0.00003762711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001155644,0.000007437482,0.0009627664,0.00001447555,0.000006559632,0.00004048059,0.000007277994,0.00002877163,0.9982363,0.0001195102,0.00001231322,0.0004485207],"study_design_scores_gemma":[0.000008602741,0.0001715438,0.02184685,0.000006681993,0.00002040356,0.000380845,0.00004769391,0.0007726804,0.9755667,0.0002312406,0.0009428986,0.000003957613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994791,0.0005094633,0.003575492,0.0001052447,0.00001800345,0.00001091074,0.0002464875,0.0000977416,0.0006455746],"genre_scores_gemma":[0.9969329,0.0003139369,0.001534615,0.00002901682,0.000005108358,0.00001683895,0.0002091767,0.00001896086,0.0009394083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212193,"threshold_uncertainty_score":0.004055142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007839153271604383,"score_gpt":0.2232134883702894,"score_spread":0.215374335098685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}