{"id":"W2917080169","doi":"10.1002/cpt.1409","title":"Clinical Pharmacogenetics Implementation Consortium Guideline for <scp>Cytochrome P450 (<i>CYP</i>)</scp><i>2D6</i> Genotype and Atomoxetine Therapy","year":2019,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institutes of Health","keywords":"Atomoxetine; CYP2D6; Pharmacogenetics; Pharmacology; Medicine; Cytochrome P450; Guideline; Genotype; Atomoxetine hydrochloride; Pharmacokinetics; Attention deficit hyperactivity disorder; Internal medicine; Psychiatry; Metabolism; Biology; Genetics; Methylphenidate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01484739,0.0009063433,0.00161867,0.002046074,0.0009687279,0.002463719,0.004082971,0.008371048,0.01634132],"category_scores_gemma":[0.04026809,0.0007074936,0.003115695,0.002028254,0.0008349379,0.001662012,0.001815089,0.008264322,0.01230416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002158212,"about_ca_system_score_gemma":0.01398774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01549562,"about_ca_topic_score_gemma":0.02390693,"domain_scores_codex":[0.9826261,0.007220693,0.00397936,0.0006835342,0.004671011,0.0008193264],"domain_scores_gemma":[0.9625732,0.01244217,0.003708506,0.001232371,0.0179142,0.002129569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002054524,0.0003609377,0.001996841,0.001240623,0.00007416064,0.0006184897,0.0002240102,0.0006233465,0.0009331962,0.005691106,0.8042957,0.1837362],"study_design_scores_gemma":[0.0008000215,0.0002972127,0.009125709,0.009041941,0.0002387941,0.001347963,0.0002151492,0.001065536,0.00124995,0.007469886,0.9690695,0.00007841553],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.007202082,0.05590318,0.07185558,0.4429372,0.01306652,0.01120144,0.02216034,0.005530579,0.3701431],"genre_scores_gemma":[0.05522039,0.08721118,0.2815403,0.3427546,0.0120799,0.02902612,0.05000086,0.002150861,0.1400159],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.01634132,"threshold_uncertainty_score":0.07852143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1334353888882253,"score_gpt":0.5070233472240556,"score_spread":0.3735879583358304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}