{"id":"W2917224498","doi":"10.1111/jcmm.14199","title":"Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post‐menopausal women with severe pelvic organ prolapse","year":2019,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Pelvic floor disorders treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"University of Toronto; University Health Network","keywords":"Elastin; Extracellular matrix; Immune system; Immunohistochemistry; Medicine; Vagina; Gene expression; Infiltration (HVAC); Andrology; Internal medicine; Biology; Pathology; Immunology; Gene; Anatomy; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001042629,0.0001138647,0.0002190211,0.0001268819,0.0001116824,0.0001411365,0.00004169698,0.0001135588,0.0008419456],"category_scores_gemma":[0.000246522,0.00008556987,0.000111996,0.0000736402,0.0001391148,0.00005581537,0.0001052374,0.0001513181,0.00009557965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005497739,"about_ca_system_score_gemma":0.00007017425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001533858,"about_ca_topic_score_gemma":0.000379821,"domain_scores_codex":[0.9999501,0.00001775466,0.000003722698,0.000006839324,0.000009081004,0.00001256145],"domain_scores_gemma":[0.9999396,0.00001616812,0.00002071586,0.000003890312,0.000005276931,0.00001434988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008752926,0.0004921787,0.1455602,0.0004555774,0.00008723002,0.002115762,0.000835789,0.0001797557,0.8029366,0.00004824559,0.0001365747,0.0383992],"study_design_scores_gemma":[0.0002045311,0.01126429,0.9451227,0.00003549554,0.0001009904,0.003231926,0.001427308,0.0002554782,0.0361375,0.00005313167,0.00215648,0.00001017304],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988685,0.000906012,0.00003835762,0.000017622,0.000003485229,0.000005477035,0.00001264468,7.6737e-7,0.0001472899],"genre_scores_gemma":[0.9989196,0.0006611219,0.00008649182,0.00002856599,0.000008557139,0.00001071135,0.00002939757,5.171922e-7,0.0002550234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008419456,"threshold_uncertainty_score":0.002816617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004287303066397283,"score_gpt":0.2359637958556414,"score_spread":0.2316764927892441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}