{"id":"W2917263971","doi":"10.1038/s41588-018-0342-2","title":"Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations","year":2019,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":423,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; St. Paul's Hospital; University of British Columbia; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Biotechnology and Biological Sciences Research Council; National Heart, Lung, and Blood Institute; Medical Research Council; National Institute for Health and Care Research; Wellcome Trust","keywords":"Biology; Phenotype; Pulmonary disease; Genetics; Disease; Genetic heterogeneity; Evolutionary biology; Gene; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008277999,0.0002586203,0.0003880679,0.0001864098,0.00008376992,0.00002777061,0.0001954005,0.0003067153,0.0004095896],"category_scores_gemma":[0.0001070904,0.0002520751,0.0001212775,0.0004591001,0.0001621538,0.00005649536,0.0002021032,0.0005619589,0.00006384482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002300735,"about_ca_system_score_gemma":0.0006294598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009122011,"about_ca_topic_score_gemma":0.000007896748,"domain_scores_codex":[0.9979772,0.00007311154,0.0003228959,0.0005424863,0.0006612689,0.000423054],"domain_scores_gemma":[0.998191,0.00009664493,0.000157187,0.0006318618,0.0005719396,0.0003513403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003908495,0.0003949086,0.970355,0.00155435,0.0002151583,0.0001976428,0.0001448041,0.0007225688,0.01867854,0.00004425804,0.0003567584,0.006945102],"study_design_scores_gemma":[0.0008486783,0.0001572286,0.989694,0.0000595923,0.000294705,0.00003530479,0.00007219282,0.004299422,0.003006701,0.0005573616,0.000741189,0.0002336258],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9236975,0.07334556,0.000006590601,0.0001092971,0.0005103723,0.0007659019,0.0002041885,0.00003585474,0.001324682],"genre_scores_gemma":[0.9964469,0.001211408,0.0003674362,0.00007214824,0.0003388261,0.00001275818,0.0001628177,0.00005951912,0.0013282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07274933,"threshold_uncertainty_score":0.9999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007434365858327551,"score_gpt":0.2635679386085148,"score_spread":0.2561335727501872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}