{"id":"W2917321490","doi":"10.1016/j.ejca.2019.01.017","title":"Neurotoxicity induced by targeted therapies in patients treated for metastatic melanoma","year":2019,"lang":"en","type":"letter","venue":"European Journal of Cancer","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Vemurafenib; Dabrafenib; Trametinib; Medicine; Melanoma; Internal medicine; Oncology; Rash; Dermatology; Cancer research; Metastatic melanoma; MAPK/ERK pathway; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003191075,0.0002953847,0.0004372498,0.0001176037,0.00002788556,0.00003055511,0.0003773248,0.0001326529,0.00004045488],"category_scores_gemma":[0.00008106976,0.0002365156,0.0002248096,0.00006560113,0.00002627157,0.000006740896,0.00004431058,0.00053666,0.000006599485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003425582,"about_ca_system_score_gemma":0.0001133477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000100945,"about_ca_topic_score_gemma":0.000004830894,"domain_scores_codex":[0.9981248,0.0005108003,0.0005604865,0.0002769372,0.000234936,0.0002920638],"domain_scores_gemma":[0.9987419,0.00002842069,0.0006915774,0.0002341987,0.0002560863,0.00004787864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003568044,0.00006678362,0.003535628,0.00007987017,0.0003134276,0.00007049187,0.00005767175,0.000004554051,0.1381047,3.45851e-7,0.8539693,0.003440348],"study_design_scores_gemma":[0.003240539,0.002430406,0.007291114,0.00008937566,0.00008851626,0.000005910248,0.000005571133,0.000002359949,0.03516297,0.000003250277,0.9513651,0.0003149242],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808972,0.002768839,0.0001198046,0.0133254,0.001086822,0.0007223926,0.0004943171,0.00000553338,0.0005796836],"genre_scores_gemma":[0.8237546,0.0004738415,0.0002470691,0.1668702,0.003601011,0.00003833944,0.001074562,0.000286616,0.003653725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1571426,"threshold_uncertainty_score":0.9644824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01783321065638458,"score_gpt":0.2468876863466996,"score_spread":0.2290544756903151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}