{"id":"W2917338125","doi":"10.1016/j.pbiomolbio.2019.02.006","title":"Targeting the CINful genome: Strategies to overcome tumor heterogeneity","year":2019,"lang":"en","type":"review","venue":"Progress in Biophysics and Molecular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Saskatchewan Cancer Agency; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Synthetic lethality; Genome instability; Telomere; Biology; Genetic heterogeneity; Genome; Computational biology; Chromosome instability; Cancer; Mutation; DNA damage; Genetics; DNA repair; Gene; DNA; Phenotype; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006489126,0.0009049472,0.001186766,0.002101897,0.0002825837,0.0009743473,0.001121666,0.00144466,0.003109276],"category_scores_gemma":[0.0005841614,0.0003355817,0.0004828933,0.00128007,0.0007639374,0.001616417,0.0008457506,0.0030018,0.002153874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009031215,"about_ca_system_score_gemma":0.0007193718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000692415,"about_ca_topic_score_gemma":0.001248912,"domain_scores_codex":[0.9998308,0.0000278208,0.00001878494,0.00003280431,0.00006634873,0.00002324932],"domain_scores_gemma":[0.9997593,0.0001229345,0.00002705952,0.00001094485,0.00005079857,0.00002908774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001025398,0.00008874996,0.0001245495,0.01229273,0.0000774692,0.0002962437,0.00007239037,0.0005971144,0.005966656,0.01608464,0.03180885,0.932488],"study_design_scores_gemma":[0.0000119907,0.00006467702,0.00023934,0.001018711,0.00003746422,0.0007654565,0.00002447261,0.00008059354,0.001028356,0.002431849,0.994285,0.00001215319],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001542943,0.9969559,0.0004492895,0.0003415358,0.0003399228,0.00000681037,0.00001623955,0.00001657769,0.001719565],"genre_scores_gemma":[0.001111896,0.9965148,0.0004640758,0.0003506153,0.0001578012,0.00001402151,0.00004469407,0.000004601543,0.001337466],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003109276,"threshold_uncertainty_score":0.01040155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01977814896021697,"score_gpt":0.3303199085880442,"score_spread":0.3105417596278273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}