{"id":"W2917355774","doi":"10.3389/fimmu.2019.00247","title":"Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Bacterial outer membrane; Antigen; Transferrin; Neisseria; Microbiology; Transferrin receptor; Biology; Epitope; Integral membrane protein; Membrane protein; Chemistry; Escherichia coli; Biochemistry; Bacteria; Membrane; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001505655,0.0003148315,0.0001884185,0.000178669,0.00008467318,0.000325983,0.0001908343,0.0002687435,0.0003875252],"category_scores_gemma":[0.0001157198,0.0001012056,0.0001990153,0.00007905816,0.0001819005,0.000135693,0.0002343947,0.0003153386,0.0001243234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001789181,"about_ca_system_score_gemma":0.00009586572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003177498,"about_ca_topic_score_gemma":0.0003693241,"domain_scores_codex":[0.9999255,0.00001748226,0.00000484898,0.00001285544,0.00001943534,0.00001982816],"domain_scores_gemma":[0.9999322,0.00001643544,0.00001434786,0.000009200545,0.000009976949,0.00001782655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006191104,0.00002358949,0.0001138671,0.00001337288,0.000003890958,0.00002531599,0.000007857433,0.0000874218,0.9983523,0.00004294072,0.000007900609,0.00125962],"study_design_scores_gemma":[0.00003639067,0.001292667,0.002691401,0.000007368759,0.00003153208,0.0004387847,0.00002603746,0.001486973,0.9923248,0.0000500323,0.001607995,0.000005913132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961298,0.0003980881,0.002853581,0.00002583353,0.000009109907,0.0000237714,0.00003488217,0.00005103774,0.0004738727],"genre_scores_gemma":[0.9968187,0.0002359767,0.00244078,0.00001927637,0.000004435527,0.00001105842,0.0001035063,0.000007384248,0.0003589746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003875252,"threshold_uncertainty_score":0.00129813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499741354565237,"score_gpt":0.2175316608873308,"score_spread":0.2025342473416784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}