{"id":"W2917355774","doi":"10.3389/fimmu.2019.00247","title":"Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Bacterial outer membrane; Antigen; Transferrin; Neisseria; Microbiology; Transferrin receptor; Biology; Epitope; Integral membrane protein; Membrane protein; Chemistry; Escherichia coli; Biochemistry; Bacteria; Membrane; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002536515,0.0001901177,0.0005055764,0.0003216636,0.00009913565,0.000008242622,0.0001838142,0.0002455084,0.0003219887],"category_scores_gemma":[0.00005720879,0.0001859072,0.0001586481,0.0002039612,0.0001448857,0.0001172966,0.00003717313,0.0002616522,0.00004131545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000406279,"about_ca_system_score_gemma":0.00006573234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007203998,"about_ca_topic_score_gemma":0.00004202404,"domain_scores_codex":[0.9986099,0.0001900437,0.0004626998,0.0003376966,0.0000102912,0.0003893532],"domain_scores_gemma":[0.999434,0.0000251203,0.0001443192,0.0003142339,0.00007337383,0.000008965057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007941598,0.0001358442,0.01495667,0.00006485204,0.000172361,3.241337e-7,0.00009551631,0.000002340679,0.977802,0.0002356875,0.0002904555,0.005449794],"study_design_scores_gemma":[0.002615157,0.0005310184,0.0336485,0.00006712761,0.00002135416,0.00002297912,0.000443257,0.00003652002,0.9312316,0.0002691555,0.03087975,0.0002335578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883009,0.0008808162,0.003941254,0.00006939627,0.004594724,0.001755136,0.0001181231,0.00005323498,0.0002863856],"genre_scores_gemma":[0.9972369,0.0001048939,0.0004611045,0.000005119369,0.00002399711,0.0001640762,0.0001306072,0.00002090176,0.001852419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04657036,"threshold_uncertainty_score":0.7581077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499741354565237,"score_gpt":0.2175316608873308,"score_spread":0.2025342473416784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}