{"id":"W2917399988","doi":"10.1182/blood-2018-99-120057","title":"Young High Risk Patients with MYC/BCL2 Double Hit Lymphoma, BCL2+ and/or Germinal Centre B-Cell like Diffuse Large B-Cell Lymphoma Benefit from Dose-Dense Chemoimmunotherapy Including Early CNS Prophylaxis: Analysis of Data from the Nordic Lymphoma Group CRY-04 and Chic Trials","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Chemoimmunotherapy; Medicine; Internal medicine; Diffuse large B-cell lymphoma; Lymphoma; BCL6; Germinal center; Gastroenterology; Oncology; Clinical trial; Rituximab; Surgery; Pathology; B cell; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002779247,0.0003627292,0.001619089,0.0002172433,0.0002363295,0.0006447745,0.0002981622,0.0004821897,0.0005718182],"category_scores_gemma":[0.00154775,0.0002189937,0.001128383,0.0003859346,0.0003576414,0.00032551,0.0002514516,0.0006479168,0.00006948665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003977951,"about_ca_system_score_gemma":0.0007274966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007378749,"about_ca_topic_score_gemma":0.00276439,"domain_scores_codex":[0.9988449,0.0008096925,0.0001054294,0.000102203,0.00007072636,0.00006713311],"domain_scores_gemma":[0.9979614,0.0009278229,0.0004631065,0.0001356936,0.0001263799,0.0003855636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7146211,0.003474163,0.2059189,0.001596012,0.009664553,0.0002597682,0.0002201658,0.002139462,0.01271814,0.0001767223,0.001497824,0.04771317],"study_design_scores_gemma":[0.161861,0.2340921,0.5699308,0.0004747631,0.01835334,0.0008170644,0.0004383578,0.001992204,0.003730811,0.0005155761,0.007714855,0.00007921334],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939628,0.00490189,0.0001031369,0.00007770026,0.00003444405,0.000152921,0.0003008749,0.000003792603,0.0004623072],"genre_scores_gemma":[0.9971584,0.001060169,0.0002947494,0.0001397372,0.00005606165,0.0001400365,0.0009477105,0.000002386801,0.0002007763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002779247,"threshold_uncertainty_score":0.01469821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244855579973748,"score_gpt":0.2585151062525909,"score_spread":0.2340295482552161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}