{"id":"W2917438066","doi":"10.1182/bloodadvances.2018028480","title":"Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"PLK1; Myeloid leukemia; Myelodysplastic syndromes; Cancer research; KRAS; NPM1; Leukemia; Biology; Medicine; Oncology; Internal medicine; Karyotype; Cancer; Cell cycle; Gene; Bone marrow; Genetics; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001480928,0.000158944,0.0003016401,0.0001102923,0.00007129858,0.00002204718,0.00004997681,0.00009220053,0.0001054029],"category_scores_gemma":[0.000112769,0.0001309358,0.00004279884,0.000247175,0.00007801592,0.0002043483,0.000100512,0.000308633,0.0002383931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005143476,"about_ca_system_score_gemma":0.00006543162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002028428,"about_ca_topic_score_gemma":0.00003445046,"domain_scores_codex":[0.9988061,0.00004582433,0.0001395639,0.0003812184,0.0003142506,0.0003130847],"domain_scores_gemma":[0.999257,0.0001305563,0.00003963486,0.0002564528,0.0001012946,0.0002150316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007238919,0.0002726333,0.05693816,0.0004213084,0.00009660725,0.000328517,0.0004381315,0.00004163679,0.9198931,0.0008295247,0.002863214,0.01715321],"study_design_scores_gemma":[0.01308745,0.0036251,0.6219302,0.000886443,0.0003650947,0.001673127,0.001617245,0.001203563,0.1612541,0.0007967778,0.1924339,0.001127057],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864433,0.0009178049,0.0000578477,0.002299797,0.00008830778,0.0006499508,0.00003769594,0.00007010822,0.009435224],"genre_scores_gemma":[0.9939811,0.0001787467,0.002835119,0.001407222,0.00020637,0.00001205515,0.00006631506,0.00002438832,0.001288724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.758639,"threshold_uncertainty_score":0.5339407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301444255122469,"score_gpt":0.281947175709457,"score_spread":0.2689327331582324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}