{"id":"W2917438066","doi":"10.1182/bloodadvances.2018028480","title":"Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"PLK1; Myeloid leukemia; Myelodysplastic syndromes; Cancer research; KRAS; NPM1; Leukemia; Biology; Medicine; Oncology; Internal medicine; Karyotype; Cancer; Cell cycle; Gene; Bone marrow; Genetics; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081016,0.0001814859,0.0002098699,0.0004356023,0.0001391607,0.0002177744,0.00009846922,0.0001561328,0.001881899],"category_scores_gemma":[0.0002882163,0.00006735623,0.0001135057,0.0002444462,0.000145762,0.00009661126,0.0001819918,0.0001303663,0.0002606341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002017101,"about_ca_system_score_gemma":0.0001084503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002717703,"about_ca_topic_score_gemma":0.0005476614,"domain_scores_codex":[0.999885,0.00001446428,0.00001464833,0.00003164072,0.00003193877,0.00002233177],"domain_scores_gemma":[0.9998608,0.00002912459,0.00005549385,0.0000166534,0.00001300288,0.00002493069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002011141,0.00008795854,0.1928014,0.00007321291,0.00003962787,0.005280833,0.0001332526,0.0003970234,0.7763692,0.0002071082,0.0002325732,0.02236667],"study_design_scores_gemma":[0.00005583446,0.001626466,0.6881971,0.00001335581,0.00009941975,0.03355736,0.0001827675,0.001138912,0.2705064,0.000311146,0.004300065,0.00001108671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985152,0.0001933375,0.0004403149,0.00002203258,0.000001788888,0.00001511312,0.0001425736,0.00001909938,0.000650496],"genre_scores_gemma":[0.9990752,0.0000875199,0.0003289424,0.00001848512,0.000003579261,0.00000778803,0.0002040863,0.000004967569,0.0002694489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001881899,"threshold_uncertainty_score":0.006295562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301444255122469,"score_gpt":0.281947175709457,"score_spread":0.2689327331582324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}