{"id":"W2917438854","doi":"10.1002/1878-0261.12471","title":"The long noncoding <scp>RNA </scp><i><scp>HORAS</scp>5</i> mediates castration‐resistant prostate cancer survival by activating the androgen receptor transcriptional program","year":2019,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Research UK; Prostate Cancer Canada","keywords":"Prostate cancer; Gene knockdown; Androgen receptor; Long non-coding RNA; RNA; Cancer research; Transcriptome; Biology; RNA-binding protein; Mediator; In vivo; Cancer; Cell biology; Gene expression; Genetics; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156057,0.0002867863,0.0001554788,0.0001399205,0.0002360685,0.0002979471,0.0002001419,0.0001791246,0.002230716],"category_scores_gemma":[0.00008783455,0.00007369633,0.0003352843,0.0001305901,0.0002378162,0.0001323815,0.0001577276,0.0005360564,0.0005666205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003328565,"about_ca_system_score_gemma":0.0002900212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008576952,"about_ca_topic_score_gemma":0.00197382,"domain_scores_codex":[0.9999069,0.00001210377,0.000008805093,0.00002305545,0.00003335653,0.00001568522],"domain_scores_gemma":[0.9999429,0.000007475313,0.0000191544,0.000007720237,0.000006533635,0.00001616202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007036463,0.00002078612,0.0003695612,0.00006394516,0.000008839631,0.00007686178,0.000008405708,0.0001500198,0.9947385,0.0003373755,0.000272689,0.003882644],"study_design_scores_gemma":[0.00002668583,0.0004659964,0.009947093,0.00001541924,0.00003316901,0.0005441152,0.00005316188,0.002085132,0.9688191,0.0001344836,0.01786526,0.00001046408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602767,0.007283757,0.01528572,0.0006240846,0.0002655361,0.0001645992,0.003597469,0.0006679229,0.01183429],"genre_scores_gemma":[0.9878507,0.001331314,0.003778209,0.0002507892,0.00003030062,0.00005045899,0.00212131,0.00004997463,0.004536922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002230716,"threshold_uncertainty_score":0.007462442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01353187151801742,"score_gpt":0.2975745159971342,"score_spread":0.2840426444791168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}