{"id":"W2917440536","doi":"10.1371/journal.pntd.0007417","title":"Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice","year":2019,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Health Resources in Action; National Institutes of Health; Sara Elizabeth O'Brien Trust; Howard Hughes Medical Institute","keywords":"Vibrio cholerae; Cholera; Immunogenicity; Cholera vaccine; Immunity; Microbiology; Biology; Cholera toxin; Immune system; Immunization; Virology; Vaccination; El Tor; Colonization; Immunology; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000006849687,0.0002393385,0.000261109,0.0001096339,0.0001253172,0.00008661728,0.0001630507,0.00009305443,0.00002005248],"category_scores_gemma":[0.0006332285,0.000200086,0.00003680823,0.0004071734,0.0000975208,0.00003469767,0.0002083625,0.0001959465,0.000006874103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006281403,"about_ca_system_score_gemma":0.0002193279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005356821,"about_ca_topic_score_gemma":0.00007379991,"domain_scores_codex":[0.9985421,0.0002490152,0.0002110868,0.0004678404,0.0001992867,0.0003306839],"domain_scores_gemma":[0.9991401,0.0000277979,0.00008359441,0.000289161,0.0002358346,0.0002234796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002066127,0.0006087662,0.1311519,0.0001610525,0.000138326,0.000007813035,0.0001074068,0.0001332652,0.8652307,0.000008546771,0.00001931205,0.000366707],"study_design_scores_gemma":[0.002452328,0.0006535875,0.9787194,0.0001766963,0.00005101909,0.000001124151,0.00003738952,0.0005725797,0.01699661,0.00002010323,0.00006614575,0.0002530747],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971169,0.0007665615,0.00008483428,0.0003867225,0.00002145481,0.001494324,0.00006571991,0.00004063644,0.00002281023],"genre_scores_gemma":[0.9986365,0.0002245526,0.0001026198,0.0001667009,0.00005225324,0.000189242,0.0005514431,0.00003442729,0.00004228076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8482341,"threshold_uncertainty_score":0.8159271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007233665622288638,"score_gpt":0.2281403185253664,"score_spread":0.2209066529030778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}