{"id":"W2917440536","doi":"10.1371/journal.pntd.0007417","title":"Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice","year":2019,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Health Resources in Action; National Institutes of Health; Sara Elizabeth O'Brien Trust; Howard Hughes Medical Institute","keywords":"Vibrio cholerae; Cholera; Immunogenicity; Cholera vaccine; Immunity; Microbiology; Biology; Cholera toxin; Immune system; Immunization; Virology; Vaccination; El Tor; Colonization; Immunology; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003123495,0.0005498611,0.0003607032,0.0005154492,0.000160693,0.0002770966,0.0002936815,0.0004328986,0.000867539],"category_scores_gemma":[0.0001662582,0.0002682083,0.000304871,0.0001660125,0.0004289667,0.0002702536,0.0002810294,0.001258182,0.0002751476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002762501,"about_ca_system_score_gemma":0.0003432416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005579766,"about_ca_topic_score_gemma":0.0008444263,"domain_scores_codex":[0.9997496,0.00003163577,0.00002167167,0.00006824372,0.00004251026,0.00008628963],"domain_scores_gemma":[0.9997994,0.00002432867,0.00005892535,0.0000321276,0.00001997877,0.00006524016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002572134,0.0001454975,0.0001655566,0.00002538036,0.000005050586,0.00001676444,0.00002629235,0.00004532317,0.998216,0.00008133939,0.00002983629,0.000985775],"study_design_scores_gemma":[0.000158829,0.00638701,0.007350191,0.00002938932,0.00004341125,0.0002313202,0.00007515227,0.0009036768,0.9822178,0.0001462067,0.002447721,0.000009268439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946728,0.0006068153,0.002287449,0.0001560601,0.00004380383,0.00006868206,0.000343442,0.0001435404,0.001677334],"genre_scores_gemma":[0.9922053,0.0008484947,0.002786179,0.0001840352,0.00002789312,0.00009236672,0.0006159426,0.00004386597,0.003195945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000867539,"threshold_uncertainty_score":0.00290221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007233665622288638,"score_gpt":0.2281403185253664,"score_spread":0.2209066529030778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}