{"id":"W2917521450","doi":"10.1073/pnas.1814711116","title":"NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Foundation Fighting Blindness; Canadian Diabetes Association; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Diabetic retinopathy; Vascular permeability; Diabetes mellitus; Medicine; Endothelial dysfunction; Nitric oxide; Pathological; Notch signaling pathway; Blindness; VE-cadherin; Endothelium; Retinopathy; Signal transduction; Cancer research; Bioinformatics; Internal medicine; Cell biology; Endocrinology; Receptor; Biology; Endothelial stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561513,0.000174653,0.0001510627,0.0002090383,0.0001341359,0.0002849659,0.00009396159,0.000219633,0.0008599258],"category_scores_gemma":[0.0001269333,0.0001192476,0.0001360383,0.0001222151,0.0001470217,0.0001536148,0.0001848709,0.0004676128,0.0001522759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003203456,"about_ca_system_score_gemma":0.0001179554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003261543,"about_ca_topic_score_gemma":0.0002894535,"domain_scores_codex":[0.9999059,0.00002164596,0.000009847993,0.00001470022,0.00002435376,0.00002351352],"domain_scores_gemma":[0.9999211,0.00001355162,0.00002078987,0.00000872969,0.000008101039,0.0000278092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002494236,0.00003414929,0.000274203,0.00002469181,0.00000465706,0.0001853119,0.00001509109,0.00004612218,0.9976532,0.0001790298,0.00004157369,0.001292643],"study_design_scores_gemma":[0.00003601191,0.0004237601,0.008784773,0.00000985813,0.00002139473,0.001291644,0.00005568031,0.001011665,0.9861617,0.0002652822,0.00193306,0.000005157787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960951,0.001393232,0.001015695,0.00009005458,0.00001599382,0.000008234641,0.0000908558,0.00004708384,0.001243758],"genre_scores_gemma":[0.9978605,0.0005732906,0.00045357,0.0000694936,0.000004340526,0.0000080414,0.00009739699,0.000006166626,0.0009272642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008599258,"threshold_uncertainty_score":0.002876699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152593786442727,"score_gpt":0.2695261473819134,"score_spread":0.2480002095174861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}