{"id":"W2917571453","doi":"10.1101/561050","title":"Oncogenic Mutations in Histologically Normal Endometrium: The New Normal?","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endometriosis Research and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"British Columbia Centre of Excellence for Women's Health; University of Calgary; Women's Health Research Institute; University of British Columbia; B.C. Women's Hospital & Health Centre; University of British Columbia Hospital; Vancouver General Hospital; BC Cancer Agency","funders":"Canadian Institutes of Health Research; BC Cancer Foundation; Canada Research Chairs; Michael Smith Health Research BC; Calgary Laboratory Services","keywords":"Endometriosis; PTEN; Malignant transformation; Adenomyosis; Endometrium; Malignancy; KRAS; Somatic cell; Immunohistochemistry; Medicine; Pathology; Germline mutation; ARID1A; Atypical hyperplasia; Carcinosarcoma; Uterus; Cancer research; Biology; Oncology; Internal medicine; Mutation; Carcinoma; Gene; Cancer; Genetics; PI3K/AKT/mTOR pathway; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00321646,0.0004525902,0.000604222,0.001618651,0.0002683298,0.001156205,0.0007752141,0.0007760334,0.002110596],"category_scores_gemma":[0.01118052,0.0002896838,0.0003075058,0.00072046,0.001810462,0.001212341,0.000734166,0.0009989233,0.0003466984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002391894,"about_ca_system_score_gemma":0.0002222775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004773123,"about_ca_topic_score_gemma":0.0004945243,"domain_scores_codex":[0.9980141,0.0006229104,0.0002443506,0.0003605502,0.0005849286,0.0001730265],"domain_scores_gemma":[0.9924817,0.002642215,0.002310898,0.001154994,0.000829143,0.0005810956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001114166,0.00005109563,0.9513314,0.0002083677,0.0001653477,0.003819621,0.0001547799,0.0001541653,0.005603848,0.0007942759,0.0005894474,0.03601337],"study_design_scores_gemma":[0.00006145539,0.001083514,0.8847131,0.0004043652,0.0004629185,0.08751612,0.001711939,0.003270633,0.004272177,0.006591658,0.009854158,0.00005796193],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701512,0.02061803,0.004393295,0.001844227,0.0002540769,0.00002127958,0.0002568695,0.00006741344,0.002393679],"genre_scores_gemma":[0.9970252,0.001908582,0.0005140163,0.000135038,0.0001555426,0.000003302422,0.00008056241,0.000008513952,0.0001690796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00321646,"threshold_uncertainty_score":0.01701045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372090764815265,"score_gpt":0.2691916096340292,"score_spread":0.2454707019858765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}