{"id":"W2917574732","doi":"10.1038/s41598-018-37287-y","title":"Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Forschungszentrum Jülich; Deutsche Forschungsgemeinschaft","keywords":"Heterologous expression; Phospholipid scramblase; Ion channel; HEK 293 cells; Biophysics; Chemistry; Intracellular; Cell biology; Ion transporter; Ligand-gated ion channel; Selectivity; Membrane potential; Biology; Biochemistry; Membrane; Receptor; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004819957,0.0001254933,0.0001059657,0.0001063624,0.0001594375,0.00009122393,0.00007450014,0.0001267774,0.0001461791],"category_scores_gemma":[0.00004608937,0.0001202402,0.00008631831,0.0002208302,0.0000561721,0.00001250421,0.00005805942,0.00006017903,0.0001357722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003898327,"about_ca_system_score_gemma":0.0001348775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002458104,"about_ca_topic_score_gemma":0.00001647491,"domain_scores_codex":[0.998457,0.00002315745,0.0002647834,0.0007206268,0.0003124117,0.000221984],"domain_scores_gemma":[0.9988657,0.000003522943,0.0001946241,0.0005747626,0.0002837412,0.00007770015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004431756,0.00008033536,0.00432994,0.00002132965,0.00003420272,0.00001575087,0.0005645439,0.0005982986,0.9257119,0.00001503797,0.06747466,0.001109705],"study_design_scores_gemma":[0.0003337252,0.0001373174,0.009250406,0.00001622556,0.0000136433,0.0001607008,0.0002585847,0.001837096,0.8966426,0.000762547,0.09029889,0.0002882461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822375,0.00007242284,0.00191734,0.0001291977,0.009696257,0.0004087347,0.000004277691,0.00002113804,0.005513157],"genre_scores_gemma":[0.9370357,0.000005406523,0.00004827944,0.0001412696,0.0002537735,0.00002543844,0.0003136445,0.00001474013,0.06216173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05664857,"threshold_uncertainty_score":0.4903253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007534262202858882,"score_gpt":0.2295023358192559,"score_spread":0.2219680736163971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}