{"id":"W2917574732","doi":"10.1038/s41598-018-37287-y","title":"Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Forschungszentrum Jülich; Deutsche Forschungsgemeinschaft","keywords":"Heterologous expression; Phospholipid scramblase; Ion channel; HEK 293 cells; Biophysics; Chemistry; Intracellular; Cell biology; Ion transporter; Ligand-gated ion channel; Selectivity; Membrane potential; Biology; Biochemistry; Membrane; Receptor; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001027755,0.0003007769,0.0001172758,0.0001213805,0.000193656,0.0002752319,0.000265114,0.0002952737,0.0007759602],"category_scores_gemma":[0.0001013097,0.0001020371,0.0001652273,0.0001080046,0.0002807305,0.0001986977,0.000253845,0.0002674581,0.0003538442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003515128,"about_ca_system_score_gemma":0.0002502373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007046356,"about_ca_topic_score_gemma":0.0005250313,"domain_scores_codex":[0.9999294,0.00000968003,0.000007775928,0.00001787376,0.00001898328,0.00001628769],"domain_scores_gemma":[0.9999044,0.000008064882,0.00003792646,0.000007698472,0.00001315871,0.00002884355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001380684,0.00001003936,0.0002050031,0.00003167074,0.000007052478,0.00006318621,0.000002992334,0.00006731303,0.9982598,0.0002275293,0.00003662187,0.0009506447],"study_design_scores_gemma":[0.00003782459,0.000187911,0.004088517,0.00001123848,0.00003218552,0.000562022,0.00002763717,0.001693502,0.9821346,0.0002273648,0.01098833,0.000008928097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868228,0.00198938,0.007446815,0.0002160049,0.0001272135,0.00003398452,0.0003271455,0.00009173774,0.002944892],"genre_scores_gemma":[0.9878985,0.001274847,0.004409683,0.00008043468,0.0000127468,0.00002393913,0.0006404585,0.00001640945,0.005642853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007759602,"threshold_uncertainty_score":0.002595842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007534262202858882,"score_gpt":0.2295023358192559,"score_spread":0.2219680736163971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}