{"id":"W2917583500","doi":"","title":"Preliminary Results of A Phase I/IIA Study of BMS-986156 (GLUCOCORTICOID-Induced Tumour Necrosis Factor Receptor-Related Gene [GITR] AGONIST), Alone and In Combination with Nivolumab in Patients with Advanced Solid Tumours","year":2017,"lang":"en","type":"article","venue":"UWA Profiles and Research Repository (University of Western Australia)","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University of Edmonton; Princess Margaret Cancer Centre","funders":"","keywords":"Agonist; Nivolumab; Glucocorticoid receptor; Glucocorticoid; Tumor necrosis factor alpha; Pharmacology; Medicine; Phase (matter); Receptor; Cancer research; Chemistry; Internal medicine; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002840329,0.002489263,0.003030799,0.0004163636,0.0007036213,0.001561819,0.000970797,0.001575017,0.004095129],"category_scores_gemma":[0.001497432,0.0007297655,0.003313473,0.000456045,0.001141798,0.001131344,0.0003642126,0.004681332,0.001518605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009843722,"about_ca_system_score_gemma":0.001926218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002051608,"about_ca_topic_score_gemma":0.006772593,"domain_scores_codex":[0.9992802,0.0003538082,0.00004104135,0.00008874584,0.00005765436,0.0001785341],"domain_scores_gemma":[0.9987798,0.0003025759,0.000133229,0.0001079341,0.00008662318,0.0005897969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5965479,0.08303501,0.00912096,0.001913005,0.004636934,0.0008612153,0.0008580941,0.007752427,0.1317888,0.0005626011,0.01356247,0.1493605],"study_design_scores_gemma":[0.3239912,0.6227593,0.02564131,0.00008810045,0.00247386,0.0007868328,0.0002133773,0.001686485,0.01146061,0.000502901,0.01031231,0.00008358726],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729676,0.006842998,0.002323253,0.002213055,0.0005328085,0.003678549,0.00489376,0.0002641817,0.006283777],"genre_scores_gemma":[0.9682277,0.005394405,0.004705896,0.002900146,0.0004678082,0.002782678,0.008793465,0.0001513608,0.006576536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004095129,"threshold_uncertainty_score":0.01502126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03203460703296727,"score_gpt":0.3184476465208435,"score_spread":0.2864130394878762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}