{"id":"W2917618392","doi":"10.15252/embr.201947792","title":"Regulating the regulator: intramembrane proteolysis of vesicular trafficking proteins and the SERCA regulator phospholamban","year":2019,"lang":"en","type":"letter","venue":"EMBO Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Proteases; Biology; Membrane protein; Phospholamban; Proteolysis; Biochemistry; Cell biology; Enzyme; Endoplasmic reticulum; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001347963,0.0004762262,0.0006871452,0.00005985792,0.0002268193,0.00008012544,0.0003119911,0.0009471937,0.00002563342],"category_scores_gemma":[0.0001245881,0.0002949426,0.0004774992,0.0001655845,0.0005254301,0.000009073936,0.000118133,0.0008577064,0.000001210484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002283935,"about_ca_system_score_gemma":0.0001768082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009795042,"about_ca_topic_score_gemma":0.00002074418,"domain_scores_codex":[0.9969226,0.0002544697,0.0009453829,0.0008587657,0.0006084206,0.0004103703],"domain_scores_gemma":[0.9968889,0.00004468141,0.001093293,0.001761538,0.0001698565,0.0000417611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007010957,0.00009838697,0.002634942,0.002223623,0.001835436,0.0007921715,0.001873559,0.0003831483,0.9433954,0.0002191541,0.04142947,0.004413642],"study_design_scores_gemma":[0.001274702,0.0001898275,0.001885556,0.0004648059,0.0006853258,0.001114978,0.0001101384,0.0002839475,0.2749161,0.0003227003,0.7178859,0.0008659894],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9414163,0.004128943,0.0007060394,0.04900548,0.0005109052,0.003584428,0.00001623744,0.00004066991,0.0005910408],"genre_scores_gemma":[0.9739298,0.0001774132,0.000378055,0.01530787,0.002202873,0.0002546974,0.003453501,0.0001725994,0.004123157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6764565,"threshold_uncertainty_score":0.9999503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004933059807378158,"score_gpt":0.1896931088429364,"score_spread":0.1847600490355582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}