{"id":"W2917714207","doi":"10.1038/s41385-019-0147-3","title":"Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis","year":2019,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McMaster University; Fonds de Recherche du Québec - Santé; Kenneth Rainin Foundation; McGill University","keywords":"Rifampicin; Tuberculosis; Pyrazinamide; Isoniazid; Mycobacterium tuberculosis; Immunology; Dysbiosis; Immunity; Medicine; Macrophage; Antibiotics; Mycobacterium; Microbiology; Immune system; Alveolar macrophage; Biology; Gut flora; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000234616,0.0002810222,0.0003094752,0.0002819712,0.0001788778,0.0005612559,0.0002152975,0.0005603947,0.001107333],"category_scores_gemma":[0.0004592676,0.0002472161,0.0001697683,0.000121037,0.0004366951,0.0002312841,0.0004450815,0.0008308486,0.0002914484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003605993,"about_ca_system_score_gemma":0.0002690156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002934845,"about_ca_topic_score_gemma":0.0005066736,"domain_scores_codex":[0.9997018,0.00007477699,0.00002375668,0.00004524878,0.00006093653,0.00009355641],"domain_scores_gemma":[0.9996798,0.00003520763,0.0001155324,0.00002908423,0.00002307736,0.0001173193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001925083,0.0001282949,0.00375302,0.00005561374,0.00001784717,0.0003289246,0.00004040888,0.00005997243,0.9892708,0.000147527,0.0000845184,0.004188092],"study_design_scores_gemma":[0.000276472,0.003781352,0.2688571,0.00007581549,0.0002202647,0.004278562,0.000902263,0.003209793,0.7108873,0.001246052,0.006237991,0.00002707136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978771,0.0008134905,0.0004530262,0.0001847022,0.00003591946,0.000008832993,0.00003896225,0.00003618851,0.0005517562],"genre_scores_gemma":[0.9988828,0.000268611,0.0002139735,0.00008639038,0.00001519741,0.000007478428,0.00002779111,0.00000956584,0.0004882095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001107333,"threshold_uncertainty_score":0.003704429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007105494534229765,"score_gpt":0.2440908416657284,"score_spread":0.2369853471314986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}