{"id":"W2917802638","doi":"10.1016/s0168-8278(08)60847-8","title":"845 PRECLINICAL PHARMACOKINETIC AND ADME CHARACTERIZATION OF VCH-916, A NOVEL NON-NUCLEOSIDE HCV NS5B POLYMERASE INHIBITOR","year":2008,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Supratek Pharma (Canada)","funders":"","keywords":"ADME; Chemistry; Pharmacokinetics; NS5B; Pharmacology; Virology; Medicine; Hepatitis C virus; Virus; Hepacivirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008171658,0.0005144591,0.0007697385,0.0003471104,0.0002442894,0.0006231617,0.000460007,0.0004055065,0.002000035],"category_scores_gemma":[0.0008367742,0.0004888102,0.0004931307,0.0003031028,0.0003667738,0.0005087083,0.0001334684,0.001529709,0.000510142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006743714,"about_ca_system_score_gemma":0.001033296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002728347,"about_ca_topic_score_gemma":0.004191107,"domain_scores_codex":[0.9996759,0.0001363192,0.00001471305,0.00003645427,0.00006629449,0.00007041416],"domain_scores_gemma":[0.9997388,0.00006653257,0.00006930563,0.00002801424,0.00003375825,0.00006366079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05482091,0.01191655,0.003812442,0.0003994367,0.0005293044,0.0003308482,0.0003070723,0.01208837,0.8114021,0.0008459301,0.004208762,0.0993384],"study_design_scores_gemma":[0.01321405,0.1997686,0.02906128,0.00004692288,0.001097218,0.001602088,0.0002334336,0.03416064,0.7035261,0.0004648109,0.01667099,0.0001538691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916698,0.001962884,0.002736541,0.0002281927,0.00007690981,0.0002529049,0.0008940719,0.0001393702,0.00203926],"genre_scores_gemma":[0.9938844,0.001247708,0.00165311,0.0001185317,0.00003687341,0.00007554312,0.000922334,0.00004925858,0.002012218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002728347,"threshold_uncertainty_score":0.0066908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686971266776195,"score_gpt":0.2978411022008163,"score_spread":0.2709713895330544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}