{"id":"W2917831885","doi":"10.1111/bph.14633","title":"Agonist‐induced desensitisation of β<sub>3</sub>‐adrenoceptors: Where, when, and how?","year":2019,"lang":"en","type":"review","venue":"British Journal of Pharmacology","topic":"Urinary Bladder and Prostate Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Ontario Drug Policy Research Network; University of Toronto","funders":"Astellas Pharma; Deutsche Forschungsgemeinschaft; Astellas Pharma Canada","keywords":"Agonist; Receptor; Endocrinology; Internal medicine; Functional selectivity; Medicine; Neuroscience; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009259225,0.0002954803,0.002231054,0.0004413529,0.00006743028,0.00005531397,0.0001872038,0.0004002394,0.0002921151],"category_scores_gemma":[0.00009967087,0.0002986832,0.0004761636,0.0002093453,0.0001841448,0.0001784689,0.0001112617,0.001381048,0.00001924332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001497636,"about_ca_system_score_gemma":0.001178199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002555231,"about_ca_topic_score_gemma":0.000007512947,"domain_scores_codex":[0.9973035,0.0006808933,0.0008526752,0.000293369,0.0004678206,0.0004017576],"domain_scores_gemma":[0.9976373,0.0003754784,0.0009825409,0.0001047379,0.0006236109,0.0002763328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001373336,0.0001819529,0.00001552757,0.01886178,0.0009016886,0.002737326,0.00006204614,9.493527e-8,0.01589585,0.000001901213,0.04037682,0.9208277],"study_design_scores_gemma":[0.004072121,0.002812437,0.0001153129,0.02160577,0.004530563,0.09919763,0.00006066787,0.000004775179,0.00907502,0.00003755748,0.8580996,0.0003885676],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0162851,0.981239,0.00001629529,0.0004035673,0.0006935659,0.001110865,0.00007675427,0.000009513753,0.0001653363],"genre_scores_gemma":[0.004812705,0.9936317,0.0001577904,0.00007238952,0.0009808366,0.00001532374,0.0000476272,0.00006937694,0.000212258],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9204391,"threshold_uncertainty_score":0.9999465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07347082919069844,"score_gpt":0.3734376855986821,"score_spread":0.2999668564079836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}