{"id":"W2917853179","doi":"10.1021/acs.jmedchem.8b01957","title":"Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer","year":2019,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McMaster University; University of Toronto","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Leukemia and Lymphoma Society of Canada; University of Toronto; Stem Cell Network; National Center for Advancing Translational Sciences; Alberta Innovates - Health Solutions; Mitacs; Indiana Clinical and Translational Sciences Institute","keywords":"Pancreatic cancer; In vivo; Histone deacetylase; Cancer research; Pharmacology; Cancer; Chemistry; Hydroxamic acid; HDAC6; Medicine; Internal medicine; Histone; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002058698,0.0004319727,0.0003575104,0.0003233569,0.0001294744,0.000243911,0.0002604674,0.0002331219,0.0005646634],"category_scores_gemma":[0.00009353927,0.0001600733,0.0003387622,0.0002461887,0.0001724031,0.0002209246,0.00008170985,0.0005312465,0.0002822902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003635384,"about_ca_system_score_gemma":0.0004275381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001867425,"about_ca_topic_score_gemma":0.002792741,"domain_scores_codex":[0.9998841,0.00001100683,0.00001055547,0.00002217771,0.00004485853,0.00002726139],"domain_scores_gemma":[0.9999262,0.000005589391,0.00001466915,0.000006674077,0.00001343622,0.00003334506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009068229,0.00005533304,0.0001421997,0.0000301836,0.000005999305,0.00002804877,0.000006576255,0.0001312295,0.9979402,0.00005833442,0.00006275019,0.001448454],"study_design_scores_gemma":[0.0000576717,0.001476448,0.005050743,0.000005419359,0.00004104015,0.0003771161,0.00001833788,0.001571686,0.9860244,0.0000298963,0.005339598,0.000007601648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972465,0.005190267,0.01427944,0.0002743788,0.00006258809,0.0003249606,0.003732543,0.0002162303,0.003454507],"genre_scores_gemma":[0.9725364,0.003913209,0.01230051,0.0001443151,0.00002139931,0.0001023115,0.00743465,0.00003833793,0.003508805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001867425,"threshold_uncertainty_score":0.003713071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403511060208406,"score_gpt":0.2772244919174978,"score_spread":0.2631893813154137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}