{"id":"W2917853179","doi":"10.1021/acs.jmedchem.8b01957","title":"Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer","year":2019,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McMaster University; University of Toronto","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Leukemia and Lymphoma Society of Canada; University of Toronto; Stem Cell Network; National Center for Advancing Translational Sciences; Alberta Innovates - Health Solutions; Mitacs; Indiana Clinical and Translational Sciences Institute","keywords":"Pancreatic cancer; In vivo; Histone deacetylase; Cancer research; Pharmacology; Cancer; Chemistry; Hydroxamic acid; HDAC6; Medicine; Internal medicine; Histone; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005150723,0.0001161445,0.0003059849,0.00007805746,0.00001389208,0.000006861365,0.0001561339,0.0001532355,0.00001729766],"category_scores_gemma":[0.00008593867,0.0001046329,0.00005802877,0.00008682882,0.0001069463,0.00001945518,0.00002716771,0.0001953755,2.31613e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005193292,"about_ca_system_score_gemma":0.0003386059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002123794,"about_ca_topic_score_gemma":0.00001433006,"domain_scores_codex":[0.9987032,0.0000598893,0.0005055132,0.0001808713,0.0004121122,0.0001383551],"domain_scores_gemma":[0.9988738,0.00001303463,0.0005470272,0.0002162114,0.00025875,0.00009116048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004035787,0.0001009163,0.0264614,0.0005367429,0.00002119763,0.000002815452,0.0001125701,0.0001700443,0.9718969,3.29471e-7,0.000006394264,0.0002870449],"study_design_scores_gemma":[0.001199655,0.0002214817,0.003966851,0.0002306377,0.00002774169,0.00001141475,0.00008135349,0.003720902,0.9904402,0.000002836938,0.00001292121,0.00008401099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991966,0.0002721002,0.0001825727,0.00008722574,0.00005699689,0.0001544081,0.00002794324,0.000001635122,0.0000205161],"genre_scores_gemma":[0.9992671,0.0001604738,0.00004959272,0.00001536114,0.0001261237,0.000008502851,0.00004726363,0.00001556053,0.0003100277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02249455,"threshold_uncertainty_score":0.4266804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403511060208406,"score_gpt":0.2772244919174978,"score_spread":0.2631893813154137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}