{"id":"W2917873126","doi":"10.1089/crispr.2018.0052","title":"Meet the Anti-CRISPRs: Widespread Protein Inhibitors of CRISPR-Cas Systems","year":2019,"lang":"en","type":"review","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CRISPR; Horizontal gene transfer; Mobile genetic elements; Biology; Plasmid; Transposable element; Trans-activating crRNA; Gene; Genetics; Genome editing; Computational biology; Bacteria; Genome; Bacterial conjugation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005923431,0.001180449,0.001275599,0.002696651,0.0002966863,0.001184921,0.001386403,0.001930073,0.004822123],"category_scores_gemma":[0.0008125156,0.0004575667,0.0005940401,0.001836753,0.0006568951,0.001693391,0.0008672503,0.003550231,0.00587819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009902748,"about_ca_system_score_gemma":0.0009369717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006979373,"about_ca_topic_score_gemma":0.001330734,"domain_scores_codex":[0.9996578,0.00004747234,0.00003901447,0.00006154097,0.0001580329,0.00003625903],"domain_scores_gemma":[0.9995142,0.0001885487,0.00006542238,0.00002247876,0.0001461042,0.00006328872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008854994,0.00006905964,0.0001140133,0.008730004,0.00008769618,0.0001989085,0.0000464925,0.0003931518,0.00457368,0.00776451,0.0593703,0.9185637],"study_design_scores_gemma":[0.00001211073,0.00004747645,0.0002037209,0.0006882933,0.00003047495,0.0005879989,0.0000130754,0.00006599245,0.0008881387,0.001264038,0.9961867,0.00001212757],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001911119,0.9931424,0.0007914618,0.0006944132,0.0008884035,0.00001520758,0.00005203918,0.00005084747,0.004174193],"genre_scores_gemma":[0.001888979,0.9897942,0.001055728,0.001098857,0.0005236784,0.00002840631,0.0001857101,0.00001423101,0.00541011],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004822123,"threshold_uncertainty_score":0.01613164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198250993016277,"score_gpt":0.3633563609090158,"score_spread":0.331373850978853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}