{"id":"W2917873126","doi":"10.1089/crispr.2018.0052","title":"Meet the Anti-CRISPRs: Widespread Protein Inhibitors of CRISPR-Cas Systems","year":2019,"lang":"en","type":"review","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CRISPR; Horizontal gene transfer; Mobile genetic elements; Biology; Plasmid; Transposable element; Trans-activating crRNA; Gene; Genetics; Genome editing; Computational biology; Bacteria; Genome; Bacterial conjugation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001590661,0.0006436468,0.001338163,0.0001366806,0.0002629068,0.0001838504,0.001420261,0.0004792714,0.00002162118],"category_scores_gemma":[0.0002509337,0.0003380863,0.0009819359,0.0002584354,0.0001926826,0.000008044592,0.0003474495,0.0009260086,0.00003491926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005140763,"about_ca_system_score_gemma":0.0004071578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003380017,"about_ca_topic_score_gemma":0.000005279578,"domain_scores_codex":[0.9966662,0.000576103,0.001239045,0.0004361901,0.0005028995,0.0005795981],"domain_scores_gemma":[0.9972901,0.0001178878,0.0009373068,0.001279495,0.0002310829,0.0001440633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002289396,0.0006237186,0.00008896312,0.07522587,0.00888326,0.0001726321,0.00153529,0.004839099,0.07292168,0.001812212,0.2793444,0.554324],"study_design_scores_gemma":[0.0002670921,0.0002023133,0.000003562553,0.005872131,0.0009336573,0.001111813,0.0002310842,0.00002474851,0.01516911,0.00002433865,0.9757041,0.0004560519],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004178989,0.9906245,0.004880528,0.0001217204,0.002035455,0.001435902,0.00005481652,0.00001382251,0.0004153094],"genre_scores_gemma":[0.01265613,0.9840111,0.00007613871,0.00003459585,0.002163478,0.0000822864,0.00002581384,0.0001367274,0.0008137801],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6963598,"threshold_uncertainty_score":0.9999071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198250993016277,"score_gpt":0.3633563609090158,"score_spread":0.331373850978853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}