{"id":"W2917933808","doi":"10.1038/s41467-019-08886-8","title":"Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Direction Générale de l’offre de Soins; Institut National Du Cancer; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Université de Genève; National and Kapodistrian University of Athens; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"Timeless; Cancer research; Oncogene; Gain of function; Biology; Cancer; Cell biology; Cell cycle; Mutation; Genetics; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007506545,0.0002853745,0.0001622986,0.0001919725,0.0001162564,0.000270621,0.0002127954,0.0002178016,0.001025755],"category_scores_gemma":[0.00008411691,0.0001188279,0.0002180124,0.0001174805,0.0001789334,0.0001814998,0.0001871121,0.0004979512,0.0002317408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003167433,"about_ca_system_score_gemma":0.0002422747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008042453,"about_ca_topic_score_gemma":0.001408522,"domain_scores_codex":[0.9998952,0.000009876848,0.00001410237,0.00002963627,0.00003048484,0.00002063325],"domain_scores_gemma":[0.9998639,0.00001451635,0.00004018588,0.00002626021,0.00001274037,0.00004247285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003452298,0.000006222074,0.00005206366,0.000007862821,0.000001793616,0.000008896812,0.000002657822,0.0000155905,0.9996163,0.00002470342,0.000008288534,0.000221068],"study_design_scores_gemma":[0.000005771329,0.000100718,0.00199062,0.000002170638,0.000006852734,0.00008982387,0.00001026722,0.0003167601,0.9964421,0.00001217721,0.001020676,0.000001948662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995901,0.0007891372,0.001907393,0.00006630246,0.00002398672,0.00002121969,0.0003909036,0.0001137621,0.0007862965],"genre_scores_gemma":[0.9949809,0.0002914466,0.001503528,0.0000301937,0.000004202425,0.00002225656,0.0006822115,0.00002236025,0.002462945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001025755,"threshold_uncertainty_score":0.003431559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007553445497799537,"score_gpt":0.2732542651925894,"score_spread":0.2657008196947899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}